Imbalance between proliferation and apoptosis− related impaired GPR30 expression is involved in preeclampsia

J Li, Z Chen, X Zhou, S Shi, H Qi, PN Baker… - Cell and Tissue …, 2016 - Springer
The proliferation and apoptosis of cells in the placenta play a critical role in preeclampsia
(PE) in which estrogen has been implicated via estrogen receptors (ERs). A novel ER, G …

[HTML][HTML] Association of a reduction of G‑protein coupled receptor 30 expression and the pathogenesis of preeclampsia

X Feng, L Zhou, X Mao, C Tong… - Molecular …, 2017 - spandidos-publications.com
Preeclampsia is a pregnancy‑specific disorder, which is a leading cause of maternal and
perinatal mortality and morbidity. A lower increase of estrogen, compared with the increase …

G protein-coupled receptor 30 regulates trophoblast invasion and its deficiency is associated with preeclampsia

C Tong, X Feng, J Chen, X Qi, L Zhou, S Shi… - Journal of …, 2016 - journals.lww.com
Background: Preeclampsia is known to be associated with reduced circulating levels of
estrogen. The effects of estrogen in preeclampsia are normally mediated by the classical …

GPR65 inhibits human trophoblast cell adhesion through upregulation of MYLK and downregulation of fibronectin via cAMP-ERK signaling in a low pH environment

J Mao, Y Feng, Y Zheng, Y Gao, L Zhang, X Sun… - Cell Communication and …, 2023 - Springer
Abstract Background Extravillous trophoblasts (EVTs) are essential cells during the
formation of the placenta, with the major function of invading the maternal decidua …

Uterine Gpr83 mRNA is highly expressed during early pregnancy and GPR83 mediates the actions of PEN in endometrial and non-endometrial cells

N Parobchak, S Rao, A Negron, J Schaefer… - F&S Science, 2020 - Elsevier
Objective To characterize the expression and signaling of uterine GPR83 in vivo in the
nonpregnant and pregnant mouse and in vitro in human endometrial and nonendometrial …

Involvement of GPR12 in the regulation of cell proliferation and survival

X Lu, N Zhang, B Meng, S Dong, Y Hu - Molecular and cellular …, 2012 - Springer
GPR12, a member of the orphan G-protein-coupled receptor family, constitutively activates
the Gs protein and increases intracellular cyclic AMP concentrations. GPR12 can be …

Hypoxia-induced GPR4 suppresses trophoblast cell migration and proliferation through the MAPK signaling pathway

H Qi, C Yao, J Xing, Y Qin - Reproductive Toxicology, 2021 - Elsevier
Abstract Pre-eclampsia (PE), a common pregnancy-systemic syndrome, is characterized by
proteinuria and hypertension and is the leading cause of maternal and fetal mortality. Thus …

Gene expression profiling reveals different molecular patterns in G-protein coupled receptor signaling pathways between early-and late-onset preeclampsia

M Liang, J Niu, L Zhang, H Deng, J Ma, W Zhou… - Placenta, 2016 - Elsevier
Early-onset preeclampsia and late-onset preeclampsia have been regarded as two different
phenotypes with heterogeneous manifestations; To gain insights into the pathogenesis of …

GPR30 regulates the EGFR-Akt cascade and predicts lower survival in patients with ovarian cancer

S Fujiwara, Y Terai, H Kawaguchi, M Takai… - Journal of ovarian …, 2012 - Springer
Objectives G protein-coupled receptor 30 (GPR30) is a 7-transmembrane estrogen receptor
that functions alongside traditional estrogen receptors to regulate the cellular responses to …

G-protein coupled receptor 64 is required for decidualization of endometrial stromal cells

JY Yoo, JI Ahn, TH Kim, S Yu, JY Ahn, JM Lim… - Scientific Reports, 2017 - nature.com
Although GPR64 has an important role for male fertility, its physiological roles in the female
reproductive system are still unknown. In the present study, immunohistochemical analysis …