To determine whether the toxic effects and changes in many cell functions caused by
antitumor 1-nitroacridines are related to their enzymatically mediated covalent interstrand …

To define a critical lesion in presumable target DNA cause in vivo by the antitumor and
cytotoxic 1-nitroacridines, Ehrlich ascites tumor (Eat) cells implanted into mice, HeLa cells …

Earlier evidence, in Part I of this paper, has shown that cytotoxic and antitumor 1-
nitroacridines did not primarily exert their potent inhibitory effects on cultured mammalian …

The mode of action of cytotoxic and antitumor 1-nitroacridines and their isomeric derivatives
was studied by comparing their effects in cell-free systems and towards cultured tumor HeLa …

Abstract Ledakrin [1-nitro-9-(3′-dimethylamino-N-propylamino) acridine], an antitumor drug
of the 1-nitro-9-aminoacridine family, was able to induce DNA-protein crosslinks in intact …

Substituted 1-nitro-9-aminoacridine derivatives were shown to inhibit RNA and to a lesser
extent protein synthesis in cultured human cells. Complex formation between the …

A 32 P-post-labeling method has been employed to detect DNA adducts formed by
derivatives of nitro-9-aminoacridine in both cellular and non-cellular systems. The treatment …

The mechanism of the biological activity of the 1-nitro and 2-nitro aminoacridine derivatives
containing the dimethylaminopropyl side chain was studied. RNA synthesis in the isolated …

Among a number of nitro derivatives of 9-aminoa with a nitro group in position 1 were found
to be the agents. While 3-nitroacridines exhibited. some potent antitum 2-and I-nitro …

Ledakrin and seven other antitumor and cytotoxic derivatives of 1-nitro-9-aminoacridine
were shown to induce DNA-single strand breaks in HeLa S3 cells as found by alkaline …