[HTML][HTML] Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice

Q Ma, BV Ineichen, M Detmar, ST Proulx - Nature communications, 2017 - nature.com
Cerebrospinal fluid (CSF) has been commonly accepted to drain through arachnoid
projections from the subarachnoid space to the dural venous sinuses. However, a lymphatic …

[HTML][HTML] Rapid lymphatic efflux limits cerebrospinal fluid flow to the brain

Q Ma, M Ries, Y Decker, A Müller, C Riner… - Acta …, 2019 - Springer
The relationships between cerebrospinal fluid (CSF) and brain interstitial fluid are still being
elucidated. It has been proposed that CSF within the subarachnoid space will enter …

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

A Aspelund, S Antila, ST Proulx, TV Karlsen… - Journal of Experimental …, 2015 - rupress.org
The central nervous system (CNS) is considered an organ devoid of lymphatic vasculature.
Yet, part of the cerebrospinal fluid (CSF) drains into the cervical lymph nodes (LNs). The …

[HTML][HTML] Magnetic resonance imaging of cerebrospinal fluid outflow after low-rate lateral ventricle infusion in mice

Y Decker, J Krämer, L Xin, A Müller, A Scheller… - JCI insight, 2022 - ncbi.nlm.nih.gov
The anatomical routes for the clearance of cerebrospinal fluid (CSF) remain incompletely
understood. However, recent evidence has given strong support for routes leading to …

[HTML][HTML] Clearance of cerebrospinal fluid from the sacral spine through lymphatic vessels

Q Ma, Y Decker, A Müller, BV Ineichen… - Journal of experimental …, 2019 - rupress.org
The pathways of circulation and clearance of cerebrospinal fluid (CSF) in the spine have yet
to be elucidated. We have recently shown with dynamic in vivo imaging that routes of outflow …

[HTML][HTML] Nasopharyngeal lymphatic plexus is a hub for cerebrospinal fluid drainage

JH Yoon, H Jin, HJ Kim, SP Hong, MJ Yang, JH Ahn… - Nature, 2024 - nature.com
Cerebrospinal fluid (CSF) in the subarachnoid space around the brain has long been known
to drain through the lymphatics to cervical lymph nodes,,,,,,,,,,,,,,,–, but the connections and …

Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid

JH Ahn, H Cho, JH Kim, SH Kim, JS Ham, I Park… - Nature, 2019 - nature.com
Recent work has shown that meningeal lymphatic vessels (mLVs), mainly in the dorsal part
of the skull, are involved in the clearance of cerebrospinal fluid (CSF), but the precise route …

[HTML][HTML] Cerebrospinal fluid outflow: a review of the historical and contemporary evidence for arachnoid villi, perineural routes, and dural lymphatics

ST Proulx - Cellular and Molecular Life Sciences, 2021 - Springer
Cerebrospinal fluid (CSF) is produced by the choroid plexuses within the ventricles of the
brain and circulates through the subarachnoid space of the skull and spinal column to …

[HTML][HTML] Cerebrospinal fluid drainage kinetics across the cribriform plate are reduced with aging

M Brady, A Rahman, A Combs, C Venkatraman… - Fluids and Barriers of …, 2020 - Springer
Background Continuous circulation and drainage of cerebrospinal fluid (CSF) are essential
for the elimination of CSF-borne metabolic products and neuronal function. While multiple …

[HTML][HTML] Clearance from the mouse brain by convection of interstitial fluid towards the ventricular system

B Bedussi, MG van Lier, JW Bartstra, J de Vos… - Fluids and Barriers of …, 2015 - Springer
Background In the absence of a true lymphatic system in the brain parenchyma, alternative
clearance pathways for excess fluid and waste products have been proposed. Suggested …