Congenital hyperinsulinism (CHI) is biochemically characterised by the dysregulated
secretion of insulin from pancreatic β-cells. It is a major cause of persistent …

Congenital hyperinsulinism (CHI) is the most important cause of persistent hypoglycaemia in
the neonate and infant. It is a clinically and genetically heterogeneous entity. The clinical …

Congenital hyperinsulinism (CHI) is a heterogenous and complex disorder in which the
unregulated insulin secretion from pancreatic beta-cells leads to hyperinsulinaemic …

Congenital hyperinsulinism (CHI) is the result of unregulated insulin secretion from the
pancreatic β-cells leading to severe hypoglycaemia. In these patients it is important to make …

Congenital hyperinsulinism (CHI or HI) is a condition leading to recurrent hypoglycemia due
to an inappropriate insulin secretion by the pancreatic islet β cells. HI has two main …

Congenital hyperinsulinism (HI) is the most frequent cause of persistent hypoglycemia in
infants and children. Delays in diagnosis and initiation of appropriate treatment contribute to …

Congenital hyperinsulinism (CHI) is a disease phenotype characterized by increased,
usually irregular, insulin secretion leading to hypoglycemia, coma, and severe brain …

Context: Hypoglycemia due to congenital hyperinsulinism (HI) is caused by mutations in 9
genes. Objective: Our objective was to correlate genotype with phenotype in 417 children …

Hyperinsulinism of infancy is a genetically heterogeneous disease characterized by
dysregulation of insulin secretion resulting in severe hypoglycemia. To date, mutations in …

Context: Congenital hyperinsulinism (HI) is the most common cause of hypoglycemia in
children. The risk of permanent brain injury in infants with HI continues to be as high as 25 …