Chronic heart failure as a state of reduced effectiveness of the natriuretic peptide system: implications for therapy

J Díez - European journal of heart failure, 2017 - Wiley Online Library
Natriuretic peptides (NPs) promote diuresis, natriuresis and vasodilation in early chronic
heart failure (CHF), countering renin–angiotensin–aldosterone system (RAAS) and …

Implications of the natriuretic peptide system in the pathogenesis of heart failure: diagnostic and therapeutic importance

Z Abassi, T Karram, S Ellaham, J Winaver… - Pharmacology & …, 2004 - Elsevier
The natriuretic peptide family consists of at least 3 structurally similar peptides: atrial
natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide …

Effects of sacubitril/valsartan on neprilysin targets and the metabolism of natriuretic peptides in chronic heart failure: a mechanistic clinical study

H Nougué, T Pezel, F Picard… - European journal of …, 2019 - Wiley Online Library
Aim This study aimed at evaluating the effects of sacubitril/valsartan on neprilysin (NEP),
and the metabolism of natriuretic peptides in heart failure (HF) and providing additional …

Attenuation of compensation of endogenous cardiac natriuretic peptide system in chronic heart failure: prognostic role of plasma brain natriuretic peptide …

T Tsutamoto, A Wada, K Maeda, T Hisanaga… - Circulation, 1997 - Am Heart Assoc
Background Patients with congestive heart failure (CHF) have high plasma levels of atrial
natriuretic peptide (ANP), mainly from the atrium, and brain natriuretic peptide (BNP), mainly …

The natriuretic peptides system in the pathophysiology of heart failure: from molecular basis to treatment

M Volpe, M Carnovali, V Mastromarino - Clinical Science, 2016 - portlandpress.com
After its discovery in the early 1980s, the natriuretic peptide (NP) system has been
extensively characterized and its potential influence in the development and progression of …

Natriuretic peptides in the pathophysiology of congestive heart failure

HH Chen, JC Burnett Jr - Current cardiology reports, 2000 - Springer
A hallmark of congestive heart failure (CHF) is the activation of the cardiac endocrine
system, in particular atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP). The …

Recent advances in natriuretic peptides in congestive heart failure

G Boerrigter, JC Burnett Jr - Expert opinion on investigational …, 2004 - Taylor & Francis
Atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) are secreted by the
heart and play important roles in the compensation of congestive heart failure with their …

The natriuretic peptide system in heart failure: Diagnostic and therapeutic implications

K Kuwahara - Pharmacology & therapeutics, 2021 - Elsevier
Natriuretic peptides, which are activated in heart failure, play an important cardioprotective
role. The most notable of the cardioprotective natriuretic peptides are atrial natriuretic …

The role of natriuretic peptides as biomarkers for guiding the management of chronic heart failure

SR Motiwala, JL Januzzi Jr - Clinical Pharmacology & …, 2013 - Wiley Online Library
The current standard treatment of chronic heart failure (HF) is based on clinical judgment,
with the goal of achieving the maximally tolerated therapeutic program. The complexity of …

Natriuretic peptide system in human heart failure.

CM Wei, DM Heublein, MA Perrella, A Lerman… - Circulation, 1993 - Am Heart Assoc
BACKGROUND Atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type
natriuretic peptide (CNP) are a family of structurally related peptides that participate in the …