Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cδ

SC Frasch, PM Henson, JM Kailey, DA Richter… - Journal of Biological …, 2000 - ASBMB
Phospholipid scramblase induces nonspecific bidirectional movement of phospholipids
across the membrane during cell activation and has been proposed to mediate the …

Phosphatidylserine exposure during apoptosis is a cell-type-specific event and does not correlate with plasma membrane phospholipid scramblase expression

B Fadeel, B Gleiss, K Högstrand, J Chandra… - Biochemical and …, 1999 - Elsevier
Phosphatidylserine (PS) exposure on the surface of cells has been considered a
characteristic feature of apoptosis. However, we demonstrate herein that externalization of …

Level of expression of phospholipid scramblase regulates induced movement of phosphatidylserine to the cell surface

J Zhao, Q Zhou, T Wiedmer, PJ Sims - Journal of Biological Chemistry, 1998 - ASBMB
We recently identified a 35-kDa erythrocyte membrane protein, phospholipid scramblase,
that promotes Ca 2+-dependent transbilayer movement of phosphatidylserine (PS) and …

Phosphorylation-mediated activation of mouse Xkr8 scramblase for phosphatidylserine exposure

T Sakuragi, H Kosako, S Nagata - Proceedings of the …, 2019 - National Acad Sciences
The exposure of phosphatidylserine (PtdSer) to the cell surface is regulated by the down-
regulation of flippases and the activation of scramblases. Xkr8 has been identified as a …

Oxidized phosphatidylcholines facilitate phospholipid flip-flop in liposomes

R Volinsky, L Cwiklik, P Jurkiewicz, M Hof… - Biophysical journal, 2011 - cell.com
Lipid asymmetry is a ubiquitous property of the lipid bilayers in cellular membranes and its
maintenance and loss play important roles in cell physiology, such as blood coagulation and …

[HTML][HTML] Identification of three new members of the phospholipid scramblase gene family

T Wiedmer, Q Zhou, DY Kwoh, PJ Sims - Biochimica et Biophysica Acta …, 2000 - Elsevier
Phospholipid (PL) scramblase is a 35 kDa protein that is thought to mediate Ca2+-induced
bidirectional transbilayer movement of plasma membrane phospholipids in activated …

Phospholipid scramblases: an overview

SK Sahu, SN Gummadi, N Manoj… - Archives of biochemistry …, 2007 - Elsevier
Phospholipid scramblases are a group of homologous proteins that are conserved in all
eukaryotic organisms. They are believed to be involved in destroying plasma membrane …

[HTML][HTML] Oxidative signaling pathway for externalization of plasma membrane phosphatidylserine during apoptosis

VE Kagan, JP Fabisiak, AA Shvedova, YY Tyurina… - FEBS letters, 2000 - Elsevier
Active maintenance of membrane phospholipid asymmetry is universal in normal cell
membranes and its disruption with subsequent externalization of phosphatidylserine is a …

Unraveling the mysteries of phospholipid scrambling

PJ Sims, T Wiedmer - Thrombosis and haemostasis, 2001 - thieme-connect.com
Plasma membrane phospholipid asymmetry is maintained by an aminophospholipid
translocase that transports phosphatidylserine (PS) and phosphatidylethanolamine (PE) …

Regulated externalization of phosphatidylserine at the cell surface: implications for apoptosis

K Balasubramanian, B Mirnikjoo, AJ Schroit - Journal of Biological …, 2007 - ASBMB
The regulated loss of plasma membrane phosphatidylserine (PS) asymmetry is critical to
many biological processes. In particular, the appearance of PS at the cell surface, a hallmark …