Endogenously synthesized n-3 polyunsaturated fatty acids in fat-1 mice ameliorate high-fat diet-induced non-alcoholic fatty liver disease

EH Kim, JS Bae, KB Hahm, JY Cha - Biochemical pharmacology, 2012 - Elsevier
Dietary n-3 polyunsaturated fatty acids (n-3 PUFAs) have well-documented protective effects
against obesity-induced insulin resistance and hepatic steatosis. Here, we investigated the …

Amelioration of non-alcoholic fatty liver disease with NPC1L1-targeted IgY or n-3 polyunsaturated fatty acids in mice

JS Bae, JM Park, J Lee, BC Oh, SH Jang, YB Lee… - Metabolism, 2017 - Elsevier
Patients with non-alcoholic fatty liver disease (NAFLD) have an increased risk for
progression to hepatocellular carcinoma in addition to comorbidities such as cardiovascular …

N-3 polyunsaturated fatty acids ameliorate hepatic steatosis via the PPAR-α/CPT-1α pathway in a mouse model of parenteral nutrition

F Tian, J Wang, H Sun, J Yang, P Wang, S Wan… - Biochemical and …, 2018 - Elsevier
Parenteral nutrition (PN) is one of the basic therapies for patients with intestinal failure;
however, hepatic steatosis associated with PN limits the long-term use of PN. N-3 …

Endogenous n‐3 Fatty Acids Alleviate Carbon‐Tetrachloride‐Induced Acute Liver Injury in Fat-1 Transgenic Mice

R Feng, M Wang, C Yan, P Li, M Chen… - Oxidative medicine …, 2016 - Wiley Online Library
n‐3 polyunsaturated fatty acids (PUFAs) are beneficial for numerous models of liver
diseases. The probable protective effects of n‐3 PUFA against carbon‐tetrachloride‐(CCl4‐) …

fat-1 mice prevent high-fat plus high-sugar diet-induced non-alcoholic fatty liver disease

X Guo, J Gao, J Li, D Li - Food & function, 2017 - pubs.rsc.org
High-fat and high-sugar (HFS) diets have been suggested to play a causal role in the
pathogenesis of non-alcoholic fatty liver disease (NAFLD). This study aimed to investigate …

Hepatic n-3 polyunsaturated fatty acid depletion promotes steatosis and insulin resistance in mice: genomic analysis of cellular targets

BD Pachikian, A Essaghir, JB Demoulin, AM Neyrinck… - PloS one, 2011 - journals.plos.org
Patients with non-alcoholic fatty liver disease are characterised by a decreased n-3/n-6
polyunsaturated fatty acid (PUFA) ratio in hepatic phospholipids. The metabolic …

Endogenously elevated n‐3 polyunsaturated fatty acids alleviate acute ethanol‐induced liver steatosis

W Huang, B Wang, X Li, JX Kang - Biofactors, 2015 - Wiley Online Library
Effective means for the prevention of alcohol‐induced liver disease, a global health problem,
have yet to be developed. We evaluated whether the high endogenous levels of omega‐3 …

Impact of dietary fat on the development of non-alcoholic fatty liver disease in Ldlr−/− mice

DB Jump, CM Depner, S Tripathy… - Proceedings of the …, 2016 - cambridge.org
The prevalence of non-alcoholic fatty liver disease (NAFLD) has increased in parallel with
central obesity and is now the most common chronic liver disease in developed countries …

Comparison of the effects of monounsaturated fatty acids and polyunsaturated fatty acids on liver lipid disorders in obese mice

W Liu, M Zhu, M Gong, W Zheng, X Zeng, Q Zheng, X Li… - Nutrients, 2023 - mdpi.com
Obesity is a recognized epidemic worldwide, and the accumulation of excess free saturated
fatty acids (SFAs) in cells induces cellular lipotoxic damage and increases the risk of a wide …

Sucrose counteracts the anti-inflammatory effect of fish oil in adipose tissue and increases obesity development in mice

T Ma, B Liaset, Q Hao, RK Petersen, E Fjære, HT Ngo… - PloS one, 2011 - journals.plos.org
Background Polyunsaturated n-3 fatty acids (n-3 PUFAs) are reported to protect against high
fat diet-induced obesity and inflammation in adipose tissue. Here we aimed to investigate if …