Building on our previous work that discovered 1, 2, 4-triazole–spirodienone as a promising
pharmacophore for anticancer activity, we have further diversified 1, 2, 4–triazole …

Starting from easy accessible pyrazoletetrahydropyran acetals, a series of new pyrazolone
spirocyclohexadienone derivatives were synthesized and assayed for antitumor activity …

To develop more effective antitumor steroidal drugs, we synthesized a library including
twenty-two novel cytotoxic 2-alkyloxyl substituted (25 R)-spirostan-1, 4, 6-triene-3-ones and …

A series of new spirooxindole derivatives (4a-4l) were designed, synthesized and
characterized, in which the structure of compound 4f was further confirmed by single X-ray …

A series of thiabendazole-derived 1, 2, 3-triazole compounds were synthesized in good
yields via 1, 3-dipolar cycloaddition through click chemistry approach using different chain …

In an endeavour to develop potent anti-tumor agents from diosgenin, a series of C-6 derived
1, 2, 3-triazolyl derivatives were designed and synthesized by employing Cu (I) catalyzed …

Several FDA approved small molecule anti-cancer drugs contain indazole scaffolds. Here,
we report the design, synthesis and biological evaluation of a series of indazole derivatives …

Spirocompounds constitute an important class of organic frameworks enveloping numerous
pharmacological activities, among them, the promising anticancer potential of …

A series of new spirooxindole-derived morpholine-fused-1, 2, 3-triazole derivatives has
been synthesized from isatin spiro-epoxides. The protocol involves regiospecific isatin …

Based on the promising results of benzenesulfonamide spirodienones as antineoplastic
agents, we have designed and synthesized a series of novel acyl sulfonamides …