The hypnozoite reservoir of Plasmodium vivax represents both the greatest obstacle and
opportunity for ultimately eradicating this species. It is silent and cannot be diagnosed until it …

Most of the tens of millions of clinical attacks caused by Plasmodium vivax each year likely
originate from dormant liver forms called hypnozoites. We do not systematically attack that …

The relapsing peculiarity of Plasmodium vivax is one of the prime reasons for sustained
global malaria transmission. Global containment of P. vivax is more challenging and crucial …

Importance Latent hepaticPlasmodium vivaxhypnozoites provoke repeated clinical attacks
called relapses. Only primaquine phosphate kills hypnozoites, and its therapeutic activity …

Plasmodium vivax relapse is one of the major causes of sustained global malaria
transmission. Primaquine (PQ) is the only commercial drug available to prevent relapses …

Background Plasmodium vivax transmission in West Africa, dominant for the Duffy-negative
blood group, has been increasingly recognized from both local residents as well as …

Primaquine Failure and Cytochrome P-450 2D6 in Plasmodium vivax Malaria | New England
Journal of Medicine Skip to main content The New England Journal of Medicine homepage …

Background Plasmodium vivax malaria is characterized by relapses arising from the
hypnozoite stages in the liver. The only currently registered drug for radical treatment to …

BACkGROunD Primaquine is currently the only medicine for treating relapses of
Plasmodium vivax and P. ovale malaria, due to its specific activity against malaria …

Background Primaquine, an 8-aminoquinoline with anti-hypnozoite activity against
Plasmodium vivax, is metabolized by human cytochrome P450 2D6 (CYP2D6) to its active …