Background: Sleep and circadian disruption (SCD) is common and severe in the ICU. On the
basis of rigorous evidence in non-ICU populations and emerging evidence in ICU …

Intensive care unit patients typically exhibit pathologic wakefulness, poor quality of daytime
sleep, nocturnal sleep fragmentation, and sleep patterns that feature the absence of slow …

Sleep is controlled by two major regulatory systems: a circadian system that drives 24-h
periodicity (Process C), and a homeostatic system (Process S) that ensures adequate …

Sleep is an important physiologic process, and lack of sleep is associated with a host of
adverse outcomes. Basic and clinical research has documented the important role circadian …

Critical illness leading to ICU admission creates and propagates a syndrome of sleep loss,
poor sleep quality, and circadian misalignment. This syndromic entity is summarized with the …

Objectives: Numerous risk factors for sleep disruption in critically ill adults have been
described. We performed a systematic review of all risk factors associated with sleep …

Objectives: Circadian rhythms are severely disrupted among the critically ill. These circadian
arrhythmias impair mentation, immunity, autonomic function, endocrine activity, hormonal …

Intensive care unit (ICU) environment is not propitious for restoring sleep. Alterations in
sleep have potential detrimental consequences explaining increasing interest in the field …

Patients in the ICU are known to have severely disrupted sleep with disturbed circadian
pattern, decreased nocturnal sleep time, abnormally increased stages 1 and 2 sleep, and …

Delirium is a syndrome characterized by acute brain failure resulting in neurocognitive
disturbances affecting attention, awareness, and cognition. It is highly prevalent among …