Enhanced permeability of the tumor vasculature allows macromolecules to enter the tumor
interstitial space, whereas the suppressed lymphatic filtration allows them to stay there. This …

Effective cancer therapy remains one of the most challenging tasks to the scientific
community, with little advancement on overall cancer survival landscape during the last two …

Nanocarriers passively accumulate in solid tumors through irregular wide fenestrations in
neovasculature and increased retention due to poor lymphatic drainage, a phenomenon …

Enhanced permeability and retention (EPR) effect is a popular strategy for targeting
nanosize anticancer drugs to tumor tissues. In this review we discuss how EPR effect …

Over the past three decades, the enhanced permeability and retention (EPR) effect has
been considered the basis of tumor-targeted drug delivery. Various cancer nanomedicines …

There has been significant debate about the nature of the enhanced permeability retention
effect (EPR) for promoting drug delivery by therapeutic nanoparticles at sites of rapid cancer …

Nanotechnology-based drug delivery platforms have been explored for cancer treatments
and resulted in several nanomedicines in clinical uses and many in clinical trials. However …

Nano-sized therapeutic agents have several advantages over low molecular weight agents
such as a larger loading capacity, the ability to protect the payload until delivery, more …

The enhanced permeability and retention (EPR) effect constitutes the rationale by which
nanotechnologies selectively target drugs to tumors. Despite promising preclinical and …

Introduction: A major problem with conventional antitumor therapeutics is nonselective
delivery of cytotoxic drugs to normal vital organs and tissues but little delivery to tumor …