Immunohistochemical Detection of Mutated BRAF V600E Supports the Clonal Origin of BRAF-Induced Thyroid Cancers Along the Spectrum of Disease Progression
RA Ghossein, N Katabi, JA Fagin - The Journal of Clinical …, 2013 - academic.oup.com
Background: The mutated BRAF V600E protein has been specifically detected in papillary
thyroid carcinomas (PTCs) using immunohistochemical (IHC) analysis. The clonal origin of …
thyroid carcinomas (PTCs) using immunohistochemical (IHC) analysis. The clonal origin of …
High-Sensitivity BRAF Mutation Analysis: BRAF V600E Is Acquired Early During Tumor Development but Is Heterogeneously Distributed in a Subset of Papillary …
D de Biase, V Cesari, M Visani… - The Journal of …, 2014 - academic.oup.com
Context: The homogeneous distribution of BRAF V600E in papillary thyroid carcinoma (PTC)
has been called into question by recent reports. These studies claim that BRAF V600E is …
has been called into question by recent reports. These studies claim that BRAF V600E is …
Detection of BRAF mutation in thyroid papillary carcinomas by mutant allele-specific PCR amplification (MASA)
MR Sapio, D Posca, G Troncone… - European Journal of …, 2006 - academic.oup.com
Objective The somatic point mutation in the BRAF gene, which results in a valine-to-
glutamate substitution at residue 600 (BRAFV600E), is an ideal hallmark of papillary thyroid …
glutamate substitution at residue 600 (BRAFV600E), is an ideal hallmark of papillary thyroid …
Clinical impact of the detection of BRAF mutations in thyroid pathology: potential usefulness as diagnostic, prognostic and theragnostic applications
S Lassalle, V Hofman, M Ilie, C Butori… - Current medicinal …, 2010 - ingentaconnect.com
A BRAF somatic mutation at residue 600 of the BRAF protein (BRAFV600E) is highly
prevalent in papillary thyroid carcinomas (PTC). This mutation occurs in approximately …
prevalent in papillary thyroid carcinomas (PTC). This mutation occurs in approximately …
Prevalence, Tumorigenic Role, and Biochemical Implications of Rare BRAF Alterations
S Barollo, R Pezzani, A Cristiani, M Redaelli… - Thyroid, 2014 - liebertpub.com
Background: Papillary thyroid carcinoma (PTC) is the most common malignant tumor of the
thyroid gland, accounting for 74–80% of all thyroid cancers. The 1799T> A transversion is an …
thyroid gland, accounting for 74–80% of all thyroid cancers. The 1799T> A transversion is an …
Immunohistochemical Investigation of BRAF p. V600E mutations in thyroid carcinoma using 2 separate BRAF antibodies
KE Fisher, SG Neill, L Ehsani, SA Caltharp… - Applied …, 2014 - journals.lww.com
Background: Approximately 45% of papillary thyroid carcinomas harbor BRAF p. V600E
mutations and current practice algorithms endorse molecular testing for BRAF p. V600E. We …
mutations and current practice algorithms endorse molecular testing for BRAF p. V600E. We …
BRAF mutation associated with other genetic events identifies a subset of aggressive papillary thyroid carcinoma
AM Costa, A Herrero, MF Fresno… - Clinical …, 2008 - Wiley Online Library
Summary Purpose BRAF V600E mutation represents the most common oncogenic event in
sporadic papillary thyroid cancer (PTC). There are, however, significant discrepancies …
sporadic papillary thyroid cancer (PTC). There are, however, significant discrepancies …
Possible involvement of BRAFV600E in altered gene expression in papillary thyroid cancer
R Watanabe, Y Hayashi, M Sassa, T Kikumori… - Endocrine …, 2009 - jstage.jst.go.jp
Somatic mutations in BRAF, especially BRAFV600E, are frequently identified in papillary
thyroid cancer (PTC) tumors. It has been established that expression levels of numbers of …
thyroid cancer (PTC) tumors. It has been established that expression levels of numbers of …
BRAF V600E maintains proliferation, transformation, and tumorigenicity of BRAF-mutant papillary thyroid cancer cells
D Liu, Z Liu, S Condouris, M Xing - The Journal of Clinical …, 2007 - academic.oup.com
Abstract Context: Although the BRAF V600E mutant can initiate the formation of papillary
thyroid cancer (PTC), it is unclear whether it is required to maintain cell proliferation …
thyroid cancer (PTC), it is unclear whether it is required to maintain cell proliferation …
Papillary thyroid carcinoma with rare exon 15 BRAF mutation has indolent behavior: a single-institution experience
L Torregrossa, D Viola, E Sensi… - The Journal of …, 2016 - academic.oup.com
Context: Approximately 40% of papillary thyroid carcinomas (PTCs) harbor the BRAF V600E
mutation, which is significantly associated with the advanced clinicopathological features of …
mutation, which is significantly associated with the advanced clinicopathological features of …
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