Therapeutic benefits from nanoparticles: the potential significance of nanoscience in diseases with compromise to the blood brain barrier

S Krol, R Macrez, F Docagne, G Defer… - Chemical …, 2013 - ACS Publications
Nanotechnology is an area of growing public interest. Its attractiveness stems from the
promise offered socially and economically by the recent significant advances in …

Nanobiotechnology-based strategies for crossing the blood–brain barrier

KK Jain - Nanomedicine, 2012 - Taylor & Francis
The blood–brain barrier (BBB) is meant to protect the brain from noxious agents; however, it
also significantly hinders the delivery of therapeutics to the brain. Several strategies have …

Targeted delivery of nano-therapeutics for major disorders of the central nervous system

H Gao, Z Pang, X Jiang - Pharmaceutical research, 2013 - Springer
Major central nervous system (CNS) disorders, including brain tumors, Alzheimer's disease,
Parkinson's disease, and stroke, are significant threats to human health. Although …

Modern methods for delivery of drugs across the blood–brain barrier

Y Chen, L Liu - Advanced drug delivery reviews, 2012 - Elsevier
The blood–brain barrier (BBB) is a highly regulated and efficient barrier that provides a
sanctuary to the brain. It is designed to regulate brain homeostasis and to permit selective …

[HTML][HTML] Current strategies to enhance delivery of drugs across the blood–brain barrier

RI Teleanu, MD Preda, AG Niculescu, O Vladâcenco… - Pharmaceutics, 2022 - mdpi.com
The blood–brain barrier (BBB) has shown to be a significant obstacle to brain medication
delivery. The BBB in a healthy brain is a diffusion barrier that prevents most substances from …

Therapeutics, imaging and toxicity of nanomaterials in the central nervous system

A Nunes, KT Al-Jamal, K Kostarelos - Journal of Controlled Release, 2012 - Elsevier
Treatment and diagnosis of neurodegenerative diseases and other CNS disorders are
nowadays considered some of the most challenging tasks in modern medicine. The …

Overcoming blood–brain barrier transport: Advances in nanoparticle-based drug delivery strategies

S Ding, AI Khan, X Cai, Y Song, Z Lyu, D Du, P Dutta… - Materials today, 2020 - Elsevier
The blood–brain barrier (BBB), a unique structure in the central nervous system (CNS),
protects the brain from bloodborne pathogens by its excellent barrier properties …

[HTML][HTML] Nanoparticle-based technology approaches to the management of neurological disorders

TM Sim, D Tarini, ST Dheen, BH Bay… - International Journal of …, 2020 - mdpi.com
Neurological disorders are the most devastating and challenging diseases associated with
the central nervous system (CNS). The blood-brain barrier (BBB) maintains homeostasis of …

Nanotechnology approaches for the regeneration and neuroprotection of the central nervous system

GA Silva - Surgical Neurology, 2005 - Elsevier
Nanotechnology is the science and engineering concerned with the design, synthesis, and
characterization of materials and devices that have a functional organization in at least 1 …

[HTML][HTML] Nanoparticle-mediated brain drug delivery: Overcoming blood–brain barrier to treat neurodegenerative diseases

C Saraiva, C Praça, R Ferreira, T Santos… - Journal of controlled …, 2016 - Elsevier
The blood–brain barrier (BBB) is a vital boundary between neural tissue and circulating
blood. The BBB's unique and protective features control brain homeostasis as well as ion …