As one of the most widespread metabolic diseases, atherosclerosis affects nearly everyone
as they age; arteries gradually narrow from plaque accumulation over time reducing …

During the past 6 years, gene expression profiling of atherosclerosis has been used to
identify genes and pathways relevant in vascular (patho) physiology. This review discusses …

BACKGROUND: Basic scientists have used preclinical animal models to explore
mechanisms driving human diseases for decades, resulting in thousands of publications …

Gene expression is altered through transcriptional regulation, and this can be a powerful
tool to determine specifically how transcription factors influence inflammationdependent …

Cardiovascular disease (CVD) is the leading cause of death in the world. Over the past
decade considerable progress has been made in understanding the genomic basis of …

The central promise of personalized medicine is individualized treatments that target
molecular mechanisms underlying the physiological changes and symptoms arising from …

In the post-genomic, big data era, our understanding of vascular diseases has been
deepened by multiple state-of-the-art “–omics” approaches, including genomics …

Recent rapid advances in genomic tools and techniques hold great promise for transforming
the practice of cardiovascular medicine. Resources including the Human Genome Project …

Transcriptomics is the study of how our genes are regulated and expressed in different
biological settings. Technical advances now enable quantitative assessment of all …

Atherosclerotic cardiovascular disease (ASCVD) proceeds through a series of stages:
initiation, progression (or regression), and complications. By integrating known biology …