IL-1β production is critically regulated by cytosolic molecular complexes, termed
inflammasomes. Different inflammasome complexes have been described to date. While all …

The NLRP3 inflammasome is a critical component of the innate immune system that
mediates caspase-1 activation and the secretion of proinflammatory cytokines IL-1β/IL-18 in …

The NLRP3 inflammasome is activated in response to a variety of signals that are indicative
of damage to the host including tissue damage, metabolic stress, and infection. Upon …

In response to infection or cell damage, inflammasomes form intracellular multimeric protein
complexes that play an essential role in host defense. Activation results in the maturation …

Inflammasomes are multi-protein signaling complexes that trigger the activation of
inflammatory caspases and the maturation of interleukin-1β. Among various inflammasome …

Inflammasomes are multiprotein complexes that serve as a platform for caspase-1 activation
and interleukin-1β (IL-1β) maturation as well as pyroptosis. Though a number of …

The NLR family, pyrin domain-containing 3 (NLRP3) inflammasome is a multiprotein
complex that activates caspase 1, leading to the processing and secretion of the pro …

ABSTRACT The NACHT, LRR and PYD domains-containing protein 3 (NLRP3)
inflammasome is a fascinating cellular machinery endowed with the capacity for rapid …

Abstract The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …

Inflammasomes continue to generate interest in an increasing number of disciplines owing
to their unique ability to integrate a myriad of signals from pathogen‐and damage …