To show that disruption of meiotic competence results in cell cycle arrest, and the production
of immature oocytes that are not capable of fertilization. Through an extensive review of …

Reproductive diseases are a long‐standing problem and have become more common in the
world. Currently, 15% of the world's population suffers from infertility, and half of them are …

Successful human reproduction requires gamete maturation, fertilization, and early
embryonic development. Human oocyte maturation includes nuclear and cytoplasmic …

Various pathogenic factors can lead to oogenesis failure and seriously affect both female
reproductive health and fertility. Genetic factors play an important role in folliculogenesis and …

Embryonic development is readily compromised by imperfections introduced during the
process of oocyte maturation. We discuss the nature and causes of these imperfections …

Oogenesis is a complex process regulated by a vast number of intra-and extra-ovarian
factors. Oogonia, which originate from primordial germ cells, proliferate by mitosis and form …

Primary ovarian insufficiency (POI), also known as premature ovarian failure, is a form of
hypergonadotropic hypogonadism that causes infertility in~ 1% of women< 40 years of age …

Maturation arrest of human oocytes may occur at various stages of the cell cycle. A total
failure of human oocytes to complete meiosis is rarely observed during assisted conception …

Ovarian failure leading to infertility can be caused by improper prenatal development of the
fetal gonad or disruption of the complex postnatal process of folliculogenesis due to …

The vertebrate ovary is an extremely dynamic organ in which excessive or defective follicles
are rapidly and effectively eliminated early in ontogeny and thereafter continuously …