Iron is an essential element that participates in numerous cellular processes. Any disruption
of iron homeostasis leads to either iron deficiency or iron overload, which can be detrimental …

Brain iron is tightly regulated by a multitude of proteins to ensure homeostasis. Iron
dyshomeostasis has become a molecular signature associated with aging which is …

The link between brain iron homeostasis and neurodegenerative disease has been the
subject of extensive research. There is increasing evidence of iron accumulation during …

Iron is a trace metal element necessary to maintain life and is also involved in a variety of
biological processes. Aging refers to the natural life process in which the physiological …

Iron is a trace element of considerable interest to both chemistry and biology. In a biological
context its chemistry is vital to the roles it performs. However, that same chemistry can …

Iron is the most abundant transition metal within the brain, and is vital for a number of
cellular processes including neurotransmitter synthesis, myelination of neurons, and …

Enormous advances have been made in the last decade in understanding iron metabolism
and iron homeostasis at both the cellular and the systemic level. This includes the …

Iron is essential for life, and the dysregulation of iron homeostasis can lead to severe
pathological changes in the neurological system. Iron deficiency slows the development of …

In a recent postmortem study, R 2* relaxometry in gray matter (GM) of the brain has been
validated as a noninvasive measure for iron content in brain tissue. Iron accumulation in the …

Brain iron deposits have been reported consistently in imaging and histologic examinations
of patients with neurodegenerative disorders. While the origins of this finding have not been …