The somatotropic axis is the central postnatal regulator of longitudinal growth. One of its
major components–growth hormone–is produced by the anterior lobe of the pituitary, which …

The pathophysiology of combined pituitary hormone deficiency (CPHD) is just beginning to
be elucidated, with mutations in genes encoding transcription factors expressed at different …

LHX3 is an LIM domain transcription factor involved in the early steps of pituitary
ontogenesis. We report here functional studies of three allelic variants, including the first …

Context: Mutations of multiple transcription factor genes involved in pituitary development
have been identified in a minor portion of patients with combined pituitary hormone …

Mechanisms that control pituitary development are gradually better understood. They
involve molecular signals from surrounding structures and the expression of a cascade of …

The anterior pituitary gland is a central regulator of growth, reproduction and homeostasis,
and is the end-product of a carefully orchestrated pattern of expression of signalling …

The past 12 years have witnessed an explosion in our understanding of the development of
the anterior pituitary gland, and of mechanisms that underlie the diagnosis of growth …

Context: Only 11 mutations have been reported in the transcription factor LHX3, known to be
important for the development of the pituitary and motor neurons. All patients were …

Definition Congenital hypopituitarism is characterized by multiple pituitary hormone
deficiency, including somatotroph, thyrotroph, lactotroph, corticotroph or gonadotroph …

The anterior pituitary gland is a central regulator of growth, reproduction and homeostasis,
and is the end-product of a carefully orchestrated pattern of expression of signalling …