Effects of empagliflozin on risk for cardiovascular death and heart failure hospitalization across the spectrum of heart failure risk in the EMPA-REG OUTCOME® trial

D Fitchett, J Butler, P van de Borne… - European heart …, 2018 - academic.oup.com
Aims Empagliflozin reduced the risk of cardiovascular (CV) death and heart failure (HF)
hospitalizations in patients with type 2 diabetes (T2D) and established CV disease (CVD) in …

Heart failure outcomes with empagliflozin in patients with type 2 diabetes at high cardiovascular risk: results of the EMPA-REG OUTCOME® trial

D Fitchett, B Zinman, C Wanner, JM Lachin… - European heart …, 2016 - academic.oup.com
Aims We previously reported that in the EMPA-REG OUTCOME® trial, empagliflozin added
to standard of care reduced the risk of 3-point major adverse cardiovascular events …

Empagliflozin reduced mortality and hospitalization for heart failure across the spectrum of cardiovascular risk in the EMPA-REG OUTCOME trial

D Fitchett, SE Inzucchi, CP Cannon, DK McGuire… - Circulation, 2019 - Am Heart Assoc
Background: In the EMPA-REG OUTCOME trial (BI 10773 [Empagliflozin] Cardiovascular
Outcome Event Trial in Type 2 Diabetes Mellitus Patients) in patients with type 2 diabetes …

Mediators of the improvement in heart failure outcomes with empagliflozin in the EMPA‐REG OUTCOME trial

D Fitchett, SE Inzucchi, B Zinman, C Wanner… - ESC Heart …, 2021 - Wiley Online Library
Abstract Aims In the EMPA‐REG OUTCOME trial, empagliflozin reduced risk of death from
heart failure (HF) or hospitalization for heart failure (HHF) versus placebo in patients with …

Efficacy of empagliflozin in patients with heart failure across kidney risk categories

J Butler, M Packer, TJ Siddiqi, M Böhm… - Journal of the American …, 2023 - jacc.org
Background Empagliflozin reduces the risk of major heart failure outcomes in heart failure
with reduced or preserved ejection fraction. Objectives The goal of this study was to evaluate …

Effect of empagliflozin on cardiovascular and renal outcomes in patients with heart failure by baseline diabetes status: results from the EMPEROR-reduced trial

SD Anker, J Butler, G Filippatos, MS Khan, N Marx… - Circulation, 2021 - Am Heart Assoc
Background: Sodium-glucose cotransporter 2 inhibitors improve outcomes in patients with
heart failure with reduced ejection fraction, but additional information is needed about …

How does empagliflozin reduce cardiovascular mortality? Insights from a mediation analysis of the EMPA-REG OUTCOME trial

SE Inzucchi, B Zinman, D Fitchett, C Wanner… - Diabetes …, 2018 - Am Diabetes Assoc
OBJECTIVE In the BI 10773 (Empagliflozin) Cardiovascular Outcome Event Trial in Type 2
Diabetes Mellitus Patients (EMPA-REG OUTCOME) trial involving 7,020 patients with type 2 …

Empagliflozin and the risk of heart failure hospitalization in routine clinical care: a first analysis from the EMPRISE study

E Patorno, A Pawar, JM Franklin, M Najafzadeh… - Circulation, 2019 - Am Heart Assoc
Background: The EMPA-REG OUTCOME trial (Empagliflozin Cardiovascular Outcome Event
Trial in Type 2 diabetes Mellitus Patients) showed that empagliflozin, a sodium-glucose …

Empagliflozin Improves Kidney Outcomes in Patients With or Without Heart Failure: Insights From the EMPA-REG OUTCOME Trial

J Butler, F Zannad, D Fitchett, B Zinman… - Circulation: Heart …, 2019 - Am Heart Assoc
Background: In EMPA-REG OUTCOME (Empagliflozin Cardiovascular Outcome Event Trial
in Type 2 Diabetes Mellitus Patients) empagliflozin significantly reduced the risk of …

Blinded withdrawal of long-term randomized treatment with empagliflozin or placebo in patients with heart failure

M Packer, J Butler, C Zeller, SJ Pocock… - Circulation, 2023 - Am Heart Assoc
BACKGROUND: It is not known whether the benefits of sodium-glucose cotransporter 2
inhibitors in heart failure persist after years of therapy. METHODS: In the EMPEROR …