The inability of insulin to stimulate glucose metabolism in skeletal muscle is a classic
characteristic of type 2 diabetes, but this insulin resistance entails altered patterns of lipid …

Obesity predisposes individuals to the development of insulin resistance, which is a risk
factor for type 2 diabetes, and muscle plays a central role in this phenomenon. Insulin …

▪ Abstract Skeletal muscle contains the majority of the body's glycogen stores and a similar
amount of readily accessible energy as intramyocellular triglyceride (imTG). While a number …

Recent evidence derived from four independent methods indicates that an excess
triglyceride storage within skeletal muscle is linked to insulin resistance. Potential …

Failure of insulin to elicit an increase in glucose uptake and metabolism in target tissues
such as skeletal muscle is a major characteristic of non-insulin dependent type 2 diabetes …

Mounting evidence indicates that elevated intramyocellular triacylglycerol concentrations
are associated with diminished insulin sensitivity in skeletal muscle. This lipid accumulation …

The prevalence of type 2 diabetes mellitus (DM2) is increasing precipitously as a
consequence of the aging population and obesity epidemic. Type 2 diabetes mellitus is …

OBJECTIVE Chronic exercise and obesity both increase intramyocellular triglycerides
(IMTGs) despite having opposing effects on insulin sensitivity. We hypothesized that …

In animal studies, increased amounts of triglyceride associated with skeletal muscle (mTG)
correlate with reduced skeletal muscle and whole body insulin action. The aim of this study …

The alarming increase in obesity and associated type 2 diabetes mellitus (T2DM) is a
paramount public health concern in developing countries. Skeletal muscle insulin resistance …