Cytokines as therapeutic targets to reduce cardiovascular risk in chronic inflammation

AM Miller, IB McInnes - Current pharmaceutical design, 2011 - ingentaconnect.com
Patients with chronic inflammatory diseases, such as rheumatoid arthritis (RA), systemic
lupus erythematosus, psoriasis and Crohn's disease have an increased atherosclerotic risk …

Anti-inflammatory therapeutics for the treatment of atherosclerosis

IF Charo, R Taub - Nature reviews Drug discovery, 2011 - nature.com
Atherosclerosis is the primary cause of heart disease and stroke and is thus the underlying
pathology of the leading causes of death in the western world. Although risk can be reduced …

Role of inflammatory cytokines in genesis and treatment of atherosclerosis

E Biros, JE Reznik, CS Moran - Trends in cardiovascular medicine, 2022 - Elsevier
Atherosclerosis demonstrates an increased rate of vascular smooth muscle cells (VSMC)
plasticity characterized by switching from the differentiated contractile phenotype to a de …

[HTML][HTML] Inflammatory therapeutic targets in coronary atherosclerosis—from molecular biology to clinical application

F Linden, G Domschke, C Erbel… - Frontiers in …, 2014 - frontiersin.org
Atherosclerosis is the leading cause of death worldwide. Over the past two decades, it has
been clearly recognized that atherosclerosis is an inflammatory disease of the arterial wall …

Updating concepts on atherosclerotic inflammation: From pathophysiology to treatment

S Ministrini, F Carbone… - European Journal of …, 2021 - Wiley Online Library
Background Atherosclerosis is recognized as a systemic low‐grade inflammatory disease.
Furthermore, the dysregulation of the inflammatory response and its timely resolution is a …

[HTML][HTML] Molecular and cellular mechanisms of inflammation in atherosclerosis

NM Popa-Fotea, CE Ferdoschi… - Frontiers in …, 2023 - frontiersin.org
Atherosclerosis and its complications are a major cause of morbidity and mortality worldwide
in spite of the improved medical and invasive treatment in terms of revascularization …

Hegemony of inflammation in atherosclerosis and coronary artery disease

A Attiq, S Afzal, W Ahmad, M Kandeel - European Journal of Pharmacology, 2024 - Elsevier
Inflammation drives coronary artery disease and atherosclerosis implications. Lipoprotein
entry, retention, and oxidative modification cause endothelial damage, triggering innate and …

[HTML][HTML] Atherosclerosis: the involvement of immunity, cytokines and cells in pathogenesis, and potential novel therapeutics

C Su, Y Lu, Z Wang, J Guo, Y Hou, X Wang… - Aging and …, 2023 - ncbi.nlm.nih.gov
As a leading contributor to coronary artery disease (CAD) and stroke, atherosclerosis has
become one of the major cardiovascular diseases (CVD) negatively impacting patients …

Inflammation: a novel therapeutic target/direction in atherosclerosis

B Li, W Li, X Li, H Zhou - Current Pharmaceutical Design, 2017 - ingentaconnect.com
Over the past two decades, the viewpoint of atherosclerosis has been replaced gradually by
a lipiddriven, chronic, low-grade inflammatory disease of the arterial wall. Current treatment …

[HTML][HTML] Inflammatory cytokines and atherosclerotic plaque progression. Therapeutic implications

AV Sterpetti - Current Atherosclerosis Reports, 2020 - Springer
Abstract Purpose of the Review Inflammatory cytokines play a major role in atherosclerotic
plaque progression. This review summarizes the rationale for personalized anti …