The link between inflammatory disorders and coronary heart disease: a look at recent studies and novel drugs in development

H Teague, NN Mehta - Current atherosclerosis reports, 2016 - Springer
Inflammation is a critical component in the development of coronary heart disease (CHD),
specifically in the process of atherogenesis. Human translational and preclinical studies …

Inflammatory cytokines and cardiovascular disease

T Ito, U Ikeda - Current Drug Targets-Inflammation & Allergy, 2003 - ingentaconnect.com
The designation of atherosclerosis as a chronic inflammatory process represents an
interesting paradigmatic shift for cardiologists. The plasma concentrations of interleukin-6 …

[HTML][HTML] Immunity, atherosclerosis and cardiovascular disease

J Frostegård - BMC medicine, 2013 - Springer
Atherosclerosis, the major cause of cardiovascular disease (CVD), is a chronic inflammatory
condition with immune competent cells in lesions producing mainly pro-inflammatory …

Potential of anti-inflammatory agents for treatment of atherosclerosis

DA Chistiakov, AA Melnichenko, AV Grechko… - … and molecular pathology, 2018 - Elsevier
Chronic inflammation is a central pathogenic mechanism of atherosclerosis induction and
progression. Vascular inflammation is associated with accelerated onset of late …

[HTML][HTML] Immunobiology of atherosclerosis: a complex net of interactions

B Herrero-Fernandez, R Gomez-Bris… - International Journal of …, 2019 - mdpi.com
Cardiovascular disease is the leading cause of mortality worldwide, and atherosclerosis the
principal factor underlying cardiovascular events. Atherosclerosis is a chronic inflammatory …

[HTML][HTML] Targeting inflammatory pathways in cardiovascular disease: the inflammasome, interleukin-1, interleukin-6 and beyond

P Libby - Cells, 2021 - mdpi.com
Recent clinical trials have now firmly established that inflammation participates causally in
human atherosclerosis. These observations point the way toward novel treatments that add …

Vascular inflammation and oxidative stress: major triggers for cardiovascular disease

S Steven, K Frenis, M Oelze, S Kalinovic… - Oxidative medicine …, 2019 - Wiley Online Library
Cardiovascular disease is a leading cause of death and reduced quality of life, proven by
the latest data of the Global Burden of Disease Study, and is only gaining in prevalence …

Targeting inflammation to reduce cardiovascular disease risk: a realistic clinical prospect?

P Welsh, G Grassia, S Botha, N Sattar… - British journal of …, 2017 - Wiley Online Library
Data from basic science experiments is overwhelmingly supportive of the causal role of
immune‐inflammatory response (s) at the core of atherosclerosis, and therefore, the …

Atherosclerosis: current pathogenesis and therapeutic options

C Weber, H Noels - Nature medicine, 2011 - nature.com
Coronary artery disease (CAD) arising from atherosclerosis is a leading cause of death and
morbidity worldwide. The underlying pathogenesis involves an imbalanced lipid metabolism …

[HTML][HTML] Anti-inflammatory and immune-modulatory therapies for preventing atherosclerotic cardiovascular disease

T Yamashita, N Sasaki, K Kasahara, K Hirata - Journal of cardiology, 2015 - Elsevier
Atherosclerosis is believed to be a chronic inflammation of the arterial wall and various
immune cells of innate and adaptive immunity involves in the pathogenesis of …