The role of pro-Inflammatory cytokines in the pathogenesis of cardiovascular disease

H Zhang, NS Dhalla - International Journal of Molecular Sciences, 2024 - mdpi.com
With cardiovascular disease (CVD) being a primary source of global morbidity and mortality,
it is crucial that we understand the molecular pathophysiological mechanisms at play …

Vascular inflammation and oxidative stress: major triggers for cardiovascular disease

S Steven, K Frenis, M Oelze, S Kalinovic… - Oxidative medicine …, 2019 - Wiley Online Library
Cardiovascular disease is a leading cause of death and reduced quality of life, proven by
the latest data of the Global Burden of Disease Study, and is only gaining in prevalence …

Atherosclerosis: current pathogenesis and therapeutic options

C Weber, H Noels - Nature medicine, 2011 - nature.com
Coronary artery disease (CAD) arising from atherosclerosis is a leading cause of death and
morbidity worldwide. The underlying pathogenesis involves an imbalanced lipid metabolism …

Targeting inflammation to reduce cardiovascular disease risk: a realistic clinical prospect?

P Welsh, G Grassia, S Botha, N Sattar… - British journal of …, 2017 - Wiley Online Library
Data from basic science experiments is overwhelmingly supportive of the causal role of
immune‐inflammatory response (s) at the core of atherosclerosis, and therefore, the …

Inflammation modulation and cardiovascular disease prevention

Z Awan, J Genest - European Journal of Preventive Cardiology, 2015 - academic.oup.com
Heart disease and stroke represent the major burden of health worldwide and account for a
staggering 17 million deaths yearly. This pandemic is, in great part preventable through …

Role of vascular inflammation in coronary artery disease: potential of anti-inflammatory drugs in the Prevention of atherothrombosis: inflammation and anti …

DM Moreira, RL da Silva, JL Vieira, T Fattah… - American Journal of …, 2015 - Springer
Coronary artery disease (CAD) and acute myocardial infarction (AMI) are inflammatory
pathologies, involving interleukins (ILs), such as IL-1β, IL-6 and tumor necrosis factor (TNF) …

Atherosclerosis: insights into vascular pathobiology and outlook to novel treatments

MP Wolf, P Hunziker - Journal of cardiovascular translational research, 2020 - Springer
The pathobiology of atherosclerosis and its current and potential future treatments are
summarized, with a spotlight on three central cell types involved:(i) endothelial cells …

Inflammation in atherosclerosis: a cause or a result of vascular disorders?

I Manduteanu, M Simionescu - Journal of cellular and …, 2012 - Wiley Online Library
Sound data support the concept that in atherosclerosis, inflammation and dyslipidemia
intersect each other and that irrespective of the initiator, both participate from the early …

Vascular macrophages in atherosclerosis

H Xu, J Jiang, W Chen, W Li… - Journal of immunology …, 2019 - Wiley Online Library
Atherosclerosis is the main pathological basis for the occurrence of most cardiovascular
diseases, the leading global health threat, and a great burden for society. It has been well …

[HTML][HTML] Anti-inflammatory and immune-modulatory therapies for preventing atherosclerotic cardiovascular disease

T Yamashita, N Sasaki, K Kasahara, K Hirata - Journal of cardiology, 2015 - Elsevier
Atherosclerosis is believed to be a chronic inflammation of the arterial wall and various
immune cells of innate and adaptive immunity involves in the pathogenesis of …