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Blood vessels are indispensable for host survival and are protected from inappropriate
inflammation by immune privilege. This protection is lost in patients with autoimmune …

Vasculitis is an autoimmune disease of unknown etiology that causes inflammation of the
blood vessels. Large vessel vasculitis is classified as either giant cell arteritis (GCA), which …

Inflammation of the human vasculature is a manifestation of many different diseases ranging
from systemic autoimmune diseases to chronic inflammatory diseases, in which multiple …

Objectives Randomised-controlled trials have recently proven the efficacy of the interleukin
(IL)-6 receptor antagonist tocilizumab (TCZ) in giant cell arteritis (GCA). However, the …

Innate immune system forms the first line of defense against foreign substances.
Neutrophils, eosinophils, erythrocytes, platelets, monocytes, macrophages, dendritic cells …

Atherosclerosis is a chronic inflammatory disease of the arterial wall where both innate and
adaptive immune responses contribute to disease initiation and progression. Recent studies …

Giant cell arteritis and Takayasu arteritis are autoimmune vasculitides that cause aneurysm
formation and tissue infarction. Extravascular inflammation consists of an intense acute …

Autoimmune and autoinflammatory diseases of the medium and large arteries, including the
aorta, cause life-threatening complications due to vessel wall destruction but also by wall …

The physiopathology of systemic sclerosis remains unclear within a complex interaction
between vasculopathy, perivascular inflammatory infiltrate, extensive tissue fibrosis and auto …