CGRP and migraine: the role of blocking calcitonin gene-related peptide ligand and receptor in the management of migraine

K Maasumi, RL Michael, AM Rapoport - Drugs, 2018 - Springer
Migraine is a highly prevalent, complex neurological disorder. The burden of disease and
the direct/indirect annual costs are enormous. Thus far, treatment options have been …

Blocking CGRP in migraine patients–a review of pros and cons

M Deen, E Correnti, K Kamm, T Kelderman… - The journal of headache …, 2017 - Springer
Migraine is the most prevalent neurological disorder worldwide and it has immense
socioeconomic impact. Currently, preventative treatment options for migraine include drugs …

Targeting CGRP: a new era for migraine treatment

S Wrobel Goldberg, SD Silberstein - CNS drugs, 2015 - Springer
Migraine is a highly prevalent headache disease that typically affects patients during their
most productive years. Despite significant progress in understanding the underlying …

CGRP monoclonal antibodies for migraine: rationale and progress

H Yuan, CG Lauritsen, EA Kaiser, SD Silberstein - BioDrugs, 2017 - Springer
Calcitonin gene-related peptide (CGRP), a neuropeptide abundant in the trigeminal system
and widely expressed in both the peripheral and central nervous systems, has recently …

CGRP-based migraine therapeutics: how might they work, why so safe, and what next?

AF Russo - ACS pharmacology & translational science, 2018 - ACS Publications
Migraine is a debilitating neurological condition that involves the neuropeptide calcitonin
gene-related peptide (CGRP). An exciting development is the recent FDA approval of the …

New trends in migraine pharmacology: targeting calcitonin gene–related peptide (CGRP) with monoclonal antibodies

D Scuteri, A Adornetto, L Rombolà… - Frontiers in …, 2019 - frontiersin.org
Migraine is a common neurologic disorder characterized by attacks consisting of unilateral,
throbbing headache accompanied by photophobia, phonophobia, and nausea which …

Calcitonin gene-related peptide receptor antagonists for migraine

MJM Fischer - Expert Opinion on Investigational Drugs, 2010 - Taylor & Francis
Importance of the field: Migraine is a highly prevalent disabling condition, and the current
treatment options are not satisfactory. The role of calcitonin gene-related peptide (CGRP) in …

Calcitonin gene-related peptide (CGRP)-targeted monoclonal antibodies and antagonists in migraine: current evidence and rationale

F Cohen, H Yuan, SD Silberstein - BioDrugs, 2022 - Springer
Calcitonin gene-related peptide (CGRP), a 37 amino-acid neuropeptide found mostly in
peptidergic sensory C-fibers, has been suggested to be implicated in the pathogenesis of …

CGRP receptor antagonists and antibodies against CGRP and its receptor in migraine treatment

L Edvinsson - British journal of clinical pharmacology, 2015 - Wiley Online Library
Recently developed calcitonin gene‐related peptide (CGRP) receptor antagonistic
molecules have shown promising results in clinical trials for acute treatment of migraine …

New drugs targeting calcitonin gene-related peptide for the management of migraines

C Tana, F Cipollone, MA Giamberardino… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Significant advances in migraine research have contributed to the development
of new drugs for the treatment of migraine. Monoclonal antibodies (mAbs) against Calcitonin …