FOXP2 was the first identified monogenic cause of a speech disorder (for review see
Graham et al., 2015). However, it remains to be answered how it affects the development of …

Speech requires precise motor control and rapid sequencing of highly complex vocal
musculature. Despite its complexity, most people produce spoken language effortlessly. This …

Human speech and language are among the most complex motor and cognitive abilities.
The discovery of a mutation in the transcription factor FOXP2 in KE family members with …

FOXP2 was the first gene shown to cause a Mendelian form of speech and language
disorder. Although developmentally expressed in many organs, loss of a single copy of …

Heterozygous mutations of the human FOXP2 transcription factor gene cause the best-
described examples of monogenic speech and language disorders. Acquisition of proficient …

That speech and language are innate capacities of the human brain has long been widely
accepted, but only recently has an entry point into the genetic basis of these remarkable …

Disruption of FOXP2, a gene encoding a forkhead‐domain transcription factor, causes a
severe developmental disorder of verbal communication, involving profound articulation …

A rare mutation affecting the Forkhead-box protein P2 (FOXP2) transcription factor causes a
severe monogenic speech and language disorder. Mice carrying an identical point mutation …

Highlights•Rare variants disrupting speech, in genes like FOXP2, give insight into
neurobiology of key human traits.•Neural functions of FOXP2 are being studied in human …

Rare disruptions of FOXP2 have been strongly implicated in deficits in language
development. Research over the past decade has suggested a role in the formation of …