Despite major progress in interventional and medical treatments, myocardial infarction (MI)
and subsequent development of heart failure (HF) are still associated with high mortality …

Ischaemia/reperfusion (I/R) injury of the heart represents a major health burden mainly
associated with acute coronary syndromes. While timely coronary reperfusion has become …

Reductions in the blood supply produce considerable injury if the duration of ischemia is
prolonged. Paradoxically, restoration of perfusion to ischemic organs can exacerbate tissue …

Mitochondria play a critical role in maintaining cellular function by ATP production. They are
also a source of reactive oxygen species (ROS) and proapoptotic factors. The role of …

Reperfusion therapy is the indispensable treatment of acute myocardial infarction (AMI) and
must be applied as soon as possible to attenuate the ischemic insult. However, reperfusion …

Mitochondria have emerged as key participants in and regulators of myocardial injury during
ischemia and reperfusion. This review examines the sites of damage to cardiac …

Acute myocardial infarction is the leading cause of cardiovascular‑related mortality and
chronic heart failure worldwide. As regards treatment, the reperfusion of ischemic tissue …

Heart tissue is remarkably sensitive to oxygen deprivation. Although heart cells, like those of
most tissues, rapidly adapt to anoxic conditions, relatively short periods of ischaemia and …

Mitochondrial reactive oxygen species (ROS) have emerged as an important mechanism of
disease and redox signaling in the cellular system. Under basal or pathological conditions …

Mitochondria are increasingly recognized as lynchpins in the evolution of cardiac injury
during ischemia and reperfusion. This review addresses the emerging concept that …