The dose-response relationship was determined in rats for the enhancement by
phenobarbital of diethylnitrosamine (DENA)-initiated neoplastic nodules and hepatocellular …

The early stages of dimethylnitrosamine (CAS: 62-75-9)-induced liver cancer and the effect
of administration of phenobarbital (CAS: 50-06-6) after dimethylnitrosamine were studied in …

Sequential feeding of various dose levels of phenobarbital (PB) after diethylnitrosamine
(DENA) administration revealed that the enhancing effect of PB on hepatocarcinogenesis …

Abstract Diethylnitrosamine (DENA, 10 mg kg-1 per day) was fed to rats for 2, 4 and 6
weeks. One week after the cessation of DENA, animals were submitted either to partial …

The effects of phenobarbital (PB) and amobarbital (AB) on the rate of development of
hepatocarcinogenesis induced by N-nitrosodiethylamine (DEN) were studied in mice …

Administration of 40 ppm diethylnitrosamine (DENA) in the drinking water for 10 weeks to
male Fischer rats led to hepatocellular carcinoma in 100%, with metastasis to the lung in …

The effect of concurrent administration of phenobarbital on the hepatocarcinogenicity of N-
nitrosodiethylamine (diethylnitrosamine; DENA) in rats was investigated by determination of …

Small doses of initiators, such as the nitrosamines, are present in the diet and man is also
exposed to promoters, such as phenobarbitone or alcohol. A simple two-stage model of rat …

A single dose of 15 mg/kg dimethylnitrosamine is an initiator of hepatic tumour formation in
rats but does not produce tumours without further treatment. Subsequent promotion by Na …

The effect of the type of carcinogen initiator on the ability of phenobarbital (PB) to promote
hepatic tumor formation in 15-day-old initiated male B6C3F1 mice was evaluated …