Yersinia pestis, the etiologic agent of plague, delivers six Yersinia outer proteins (Yops) into
host cells upon direct bacterial contact. One of these, YopM, is necessary for virulence in a …

The virulence of the pathogenic Yersinia species depends on a plasmid-encoded type III
secretion system that transfers six Yop effector proteins into host cells. One of these proteins …

An important virulence strategy evolved by bacterial pathogens to overcome host defenses
is the modulation of host cell death. Previous observations have indicated that Yersinia …

YopM, a protein toxin of Yersinia pestis, is necessary for virulence in a mouse model of
systemic plague. We previously reported YopM-dependent natural killer (NK) cell depletion …

Although adhesion to host cells is a critical step in the delivery of cytotoxic Yop proteins by
Yersinia pestis, the mechanism has not been defined. To identify adhesins critical for Yop …

To establish a successful infection, Yersinia pestis requires the delivery of cytotoxic Yops to
host cells. Yops inhibit phagocytosis, block cytokine responses, and induce apoptosis of …

Bubonic plague (a fatal, flea-transmitted disease) remains an international public health
concern. Although our understanding of the pathogenesis of bubonic plague has improved …

YopM of Yersinia pestis has previously been shown to be necessary for full virulence in mice
and to be able to bind human alpha-thrombin. This activity prompted the hypothesis that …

In Yersinia pestis KIM there are 11 Yops (yersinial outer membrane proteins) encoded by
the low-Ca2+ response virulence plasmid pCD1. Only YopM and YopN are found in easily …

Numerous microbial pathogens modulate or interfere with cell death pathways in cultured
cells. However, the precise role of host cell death during in vivo infection remains poorly …