Global Gene Expression Profiling of Yersinia pestis Replicating inside Macrophages Reveals the Roles of a Putative Stress-Induced Operon in Regulating Type III …

HS Fukuto, A Svetlanov, LE Palmer… - Infection and …, 2010 - Am Soc Microbiol
Yersinia pestis, the causative agent of plague, is a facultative intracellular pathogen.
Previous studies have indicated that the ability of Y. pestis to survive inside macrophages …

Role of YopP in Suppression of Tumor Necrosis Factor Alpha Release by Macrophages during YersiniaInfection

A Boland, GR Cornelis - Infection and immunity, 1998 - Am Soc Microbiol
ABSTRACT The Yersinia plasmid-encoded Yop virulon enables extracellular adhering
bacteria to deliver toxic effector proteins inside their target cells. It includes a type III …

The C-Terminal Tail of Yersinia pseudotuberculosis YopM Is Critical for Interacting with RSK1 and for Virulence

MW McCoy, ML Marré, CF Lesser… - Infection and …, 2010 - Am Soc Microbiol
Yersinia spp. undermine the immune responses of infected animals by translocating Yops
directly into host cells with a type III secretion system. YopM, a leucine-rich repeat protein, is …

Structure–function analysis of Yersinia pestis YopM's interaction with α-thrombin to rule on its significance in systemic plague and to model YopM's mechanism of …

J Hines, EÇ Skrzypek, AV Kajava, SC Straley - Microbial pathogenesis, 2001 - Elsevier
The plague virulence protein YopM of Yersinia pestis KIM5 belongs to the large family of
leucine-rich repeat (LRR) proteins. The only activity demonstrated so far for YopM is …

Delineation of Regions of the Yersinia YopM Protein Required for Interaction with the RSK1 and PRK2 Host Kinases and Their Requirement for Interleukin-10 …

JB McPhee, P Mena, JB Bliska - Infection and immunity, 2010 - Am Soc Microbiol
ABSTRACT The YopM protein of Yersinia sp. is a type III secreted effector that is required for
virulence in murine models of infection. YopM has previously been shown to contain leucine …

Yersinia-induced Apoptosis In Vivo Aids in the Establishment of a Systemic Infection of Mice

DM Monack, J Mecsas, D Bouley… - The Journal of …, 1998 - rupress.org
Pathogenic Yersinia cause a systemic infection in mice that is dependent on the presence of
a large plasmid encoding a number of secreted virulence proteins called Yops. We …

YERSINIA OUTER PROTEINS: Role in Modulation of Host Cell Signaling Responses and Pathogenesis

GI Viboud, JB Bliska - Annu. Rev. Microbiol., 2005 - annualreviews.org
A type III secretion system (TTSS) is encoded on a virulence plasmid that is common to three
pathogenic Yersinia species: Y. enterocolitica, Y. pseudotuberculosis, and Y. pestis …

Defective Innate Cell Response and Lymph Node Infiltration Specify Yersinia pestis Infection

F Guinet, P Avé, L Jones, M Huerre, E Carniel - PloS one, 2008 - journals.plos.org
Since its recent emergence from the enteropathogen Yersinia pseudotuberculosis, Y. pestis,
the plague agent, has acquired an intradermal (id) route of entry and an extreme virulence …

Anti-V antigen antibody protects macrophages from Yersinia pestis-induced cell death and promotes phagocytosis

S Weeks, J Hill, A Friedlander, S Welkos - Microbial pathogenesis, 2002 - Elsevier
The pathogenic Yersinia spp. harbor a common plasmid (pYV) essential for virulence. The
plasmid encodes a type III secretion system that functions to translocate Yersinia outer …

yadBC of Yersinia pestis, a New Virulence Determinant for Bubonic Plague

S Forman, CR Wulff, T Myers-Morales… - Infection and …, 2008 - Am Soc Microbiol
In all Yersinia pestis strains examined, the adhesin/invasin yadA gene is a pseudogene, yet
Y. pestis is invasive for epithelial cells. To identify potential surface proteins that are …