The oocyte requires a vast supply of energy after fertilization to support critical events such
as spindle formation, chromatid separation, and cell division. Until blastocyst implantation …

This review examines the place of mitochondria in the life cycle through oogenesis,
ovulation and early embryogenesis. Mitochondria are semi-autonomous organelles …

OBJECTIVE: To quantify the mitochondrial DNA contents in human embryos with good or
poor quality at the 8-cell stage. DESIGN: Prospective study. SETTING: Private infertility clinic …

One of the most critical issues to be solved in reproductive medicine is the treatment of
patients with multiple failures of assisted reproductive treatment caused by low-quality …

STUDY QUESTION What are the molecular differences between mitochondrial DNA
(mtDNA)-deficient and mtDNA-normal oocytes and how does mitochondrial …

Premature ovarian insufficiency (POI) is defined as the cessation of ovarian function under
the age of 40 years and is characterized by amenorrhea, hypoestrogenism, and elevated …

Purpose The oxygen consumption rates (OCRs) in mice and cattle have been reported to
change during preimplantation embryogenesis. On the other hand, mitochondrial DNA …

In addition to their role in generating energy (ATP), other possible regulatory functions for
mitochondria in the mature oocyte, preimplantation stage embryo and differentiating …

Cellular ATP is mainly generated through mitochondrial oxidative phosphorylation, which is
dependent on mitochondrial DNA (mtDNA). We have previously demonstrated the …

STUDY QUESTION What part do mitochondria play in cases of diminished ovarian reserve
(DOR)? SUMMARY ANSWER Mitochondrial biogenesis in cumulus cells may be linked with …