Various pathogenic factors can lead to oogenesis failure and seriously affect both female
reproductive health and fertility. Genetic factors play an important role in folliculogenesis and …

Background: The objective of this study was determination of the changes in the reactive
oxygen species (ROS) level, mitochondrial DNA (mtDNA) copy number and enzyme activity …

Mitochondrial metabolic capacity and DNA replication have both been shown to affect
oocyte quality, but it is unclear which one is more critical. In this study, immature oocytes …

Mitochondria play an essential role in generating energy for embryo development and
maintaining embryo metabolism through key cellular functions including ion homeostasis …

This review examines current understanding of mammalian mitochondria and mitochondrial
DNA in the light of new reproductive technologies. Mitochondria are central to ageing …

Mitochondria play a vital role in the metabolism of energy-containing compounds in the
oocyte cytoplasm to provide adenosine trisphosphate for fertilization and preimplantation …

Oocyte mitochondrial dysfunction has been proposed as a cause of high levels of
developmental retardation and arrest that occur in human preimplantation embryos …

A retrospective case control study was undertaken at the molecular biology department of a
private center for reproductive medicine in order to determine whether any correlation exists …

The role of mitochondria as a nexus of developmental regulation in mammalian oogenesis
and early embryogenesis is emerging from basic research in model species and from …

Background Female fertility declines with age, due to increased chromosomal aneuploidy
and possible reduced mitochondrial function in the embryo. Methods This review outlines …