Infertility affects around 8% of couples with a slight change in percentage in the last years.
Despite the significant efforts made in Assisted Reproductive Technologies (ARTs) in …

Mitochondria is a powerhouse organelle involved in ATP synthesis, calcium signaling,
reactive oxygen species (ROS) by oxidative stress production, cell cycle arrest via apoptosis …

There is increasing evidence in humans that abnormal mitochondrial DNA (mtDNA) is
associated with common degenerative disorders of the twenty-first century. MtDNA is …

OBJECTIVE: To determine the impact of reproductive aging on oocyte mitochondrial
quantity, function, and DNA (mtDNA) integrity. DESIGN: Prospective observational study …

STUDY QUESTION Does maternal ageing and ovarian stimulation alter mitochondrial DNA
(mtDNA) copy number and gene expression of oocytes and cumulus cells from a novel …

Abstract STUDY QUESTION Do mitochondrial DNA (mtDNA) copy number and
heteroplasmy in human embryos affect the ongoing pregnancy rate? SUMMARY ANSWER …

Optimal energy production is required for oocyte and embryo development, and
mitochondrial abnormalities have devastating reproductive consequences. Improvement of …

With the nucleus as an exception, mitochondria are the only animal cell organelles
containing their own genetic information, called mitochondrial DNA (mtDNA). During oocyte …

Along with the decline in oocyte quality, numerous defects such as mitochondrial
insufficiency and the increase of mutation and deletion have been reported in oocyte …

Purpose: To evaluate the correlation between the presence of a newly described
mitochondrial DNA (mtDNA) mutation (Δ mtDNA 5286), patients' age, and in vitro fertilization …