Type I interferon is widely used for antiviral therapy, yet has yielded disappointing results
toward chronic HBV infection. Here we identify that PEG-IFNα-2b therapy toward persistent …

Approximately 500 million people worldwide are chronically infected with the hepatitis B
virus (HBV) or hepatitis C virus (HCV), and are therefore at an increased risk for developing …

The standard of care for chronic hepatitis C, pegylated interferon-α (IFN-α) and ribavirin
(RBV), causes a sustained virologic response (SVR) in approximately 50% of patients. SVR …

During viral infections, an immediate host response is the expression of type I interferons
(IFNs). These cytokines exhibit different activities such as antiviral, immunomodulatory or …

It is known that host cells can produce type I IFNs (IFN-αβ) after exposure to conserved
bacterial products, but the functional consequences of such responses on the outcome of …

The human interferon (IFN) response is a key innate immune mechanism to fight virus
infection. IFNs are host‐encoded secreted proteins, which induce IFN‐stimulated genes …

The interferons (IFNs) are glycoproteins with strong antiviral activities that represent one of
the first lines of host defense against invading pathogens. These proteins are classified into …

A key player in driving cellular immunity, IFN-γ is capable of orchestrating numerous
protective functions to heighten immune responses in infections and cancers. It can exhibit …

Although IFN-α forms the foundation of therapy for chronic hepatitis C, only a minority of
patients has a sustained response to IFN-α alone. The antiviral activities of IFN-α formed the …

Since the discovery of the protein" interferon" over 50 years ago, IFNβ, an antiviral cytokine,
has been well studied. In particular, the pathways inducing this cytokine during viral infection …