Type I interferon (IFN), as its name implies,'interferes' with virus replication by activating
numerous genes. Further, virus-induced type I IFN regulates the magnitude and functions of …

Efficient IFN-α/β gene induction in virus-infected cells is an event central to innate immunity,
in which the transcription factor IRF-7 plays a critical role together with IRF-3. Unlike IRF-3 …

Highlights•Current IFN therapy, although commonly used in the clinic, is based on IFN-α and
is highly questionable.•Introduction of IFN-λ would provide a new IFN with specific-cell …

Abstract Interferon-α (IFN-α) has proven to be a clinically effective antiviral and
antineoplastic therapeutic drug for more than 16 years. During this time, evidence from in …

Type I IFNs (IFNα/β) are essential anti-viral cytokines produced in response to the detection
of viral components by host pattern recognition receptors. IFNα/β production is transient, and …

During the past decade, increased emphasis has been placed on finding alternatives to IFN-
α-based therapies. One such alternative, IFN-λ, has shown therapeutic promise in a variety …

Hepatitis B virus is an enveloped DNA virus, that infects more than three hundred and sixty
million people worldwide and leads to severe chronic liver diseases. Interferon-alpha …

Rapidly developing Ab responses to influenza virus provide immune protection even during
a primary infection. How these early B cell responses are regulated is incompletely …

Compared with the ubiquitous expression of type I (IFNα and IFNβ) interferon receptors, type
III (IFNλ) interferon receptors are mainly expressed in epithelial cells of mucosal barriers of …

Kaposi's sarcoma-associated herpesvirus (KSHV) is associated with vascular endothelial
cell tumor, Kaposi's sarcoma (KS) and lymphoproliferative disorder, multicentric Castleman's …