TNF and type I interferons (IFNs) are induced by microbial stimuli and mediate innate
immune responses. They are also involved in the pathogenesis of chronic inflammatory …

Type I interferons (IFNs) are critical effector cytokines of the immune system and were
originally known for their important role in protecting against viral infections; however, they …

Interferon (IFN)-α is able to stimulate many cellular genes and inhibit the replication of
various viruses. However, it is unknown whether some IFN-stimulated genes (ISGs) …

Since its discovery in 2013, interferon lambda 4 (IFN-λ4) has received a reputation as a
paradoxical type III IFN. Difficulties in detecting IFN-λ4, especially in secreted form even led …

Lambda interferon (IFN-λ) induces an intracellular IFN-α/β-like antiviral response through a
receptor complex distinct from the IFN-α/β receptor. We therefore determined the ability of …

Over the last few decades, accumulating evidence has demonstrated that numerous
Interferon (IFN) stimulate genes (ISGs) can be directly upregulated following virus infection …

Interferons (IFNs) were discovered more than half a century ago, and extensive research
has since identified multifarious roles for type I IFN in human immune responses. Here, we …

For a long time, the family of type I interferons (IFN‐α/β) has received little attention outside
the fields of virology and tumor immunology. In recent years, IFN‐α/β regained the interest of …

Interferon (IFN)-α, a type-I IFN, is widely used to treat chronic hepatitis C virus infection, but
the broad expression of IFN-α receptors often leads to adverse reactions in many organs …

We describe a novel function for the interferon (IFN)-induced protein 44-like (IFI44L) gene in
negatively modulating innate immune responses induced after virus infections. Furthermore …