Extension of the dissolution-precipitation model for kinetic elucidation of solvent-mediated polymorphic transformations
P Jakubiak, F Schuler, R Alvarez-Sánchez - European Journal of …, 2016 - Elsevier
Thorough understanding and control of the different crystal forms of a drug product is key for
fine chemistry and materials science; it ultimately determines the product's physicochemical …
fine chemistry and materials science; it ultimately determines the product's physicochemical …
Kinetics of the solution-mediated polymorphic transformation of organic compounds
L Wantha - Current Pharmaceutical Design, 2018 - ingentaconnect.com
Polymorphism is a behavior of a substance to crystallize into more than one district crystal
structures. Preferential formation of a polymorph depends strongly on the kinetics of the …
structures. Preferential formation of a polymorph depends strongly on the kinetics of the …
Manipulation of pharmaceutical polymorphic transformation process using excipients
B Tian, Z Ding, S Zong, J Yang, N Wang… - Current …, 2020 - ingentaconnect.com
Background: In the pharmaceutical field, it is vital to ensure a consistent product containing a
single solid-state form of the active pharmaceutical ingredient (API) in the drug product …
single solid-state form of the active pharmaceutical ingredient (API) in the drug product …
Polymorphic phase transitions: Macroscopic theory and molecular simulation
J Anwar, D Zahn - Advanced Drug Delivery Reviews, 2017 - Elsevier
Transformations in the solid state are of considerable interest, both for fundamental reasons
and because they underpin important technological applications. The interest spans a wide …
and because they underpin important technological applications. The interest spans a wide …
Polymorph transformation of solid drugs
Q Zhang, XF Mei - Yao xue xue bao= Acta Pharmaceutica Sinica, 2015 - europepmc.org
For the minimized phase transtorming risk, the most stable polymorph is generally
considered as the desirable solid form for pharmaceutical applications. However …
considered as the desirable solid form for pharmaceutical applications. However …
A thermodynamic-based approach to analyzing a highly solvating polymorphic system: The desolvation window method
B Samas, C Seadeek, AM Campeta… - Journal of pharmaceutical …, 2011 - Elsevier
There are two major challenges in developing a solid form:(1) identifying the
thermodynamically stable form and (2) determining the method used to crystallize that form …
thermodynamically stable form and (2) determining the method used to crystallize that form …
Solvent-interactive transformations of pharmaceutical compounds
ME Aucamp, W Liebenberg… - Advanced Topics in …, 2015 - books.google.com
A major factor which determines the overall success of a pharmaceutical product is the
solidstate form in which the active pharmaceutical compound exists. It is a well-known fact …
solidstate form in which the active pharmaceutical compound exists. It is a well-known fact …
Modeling solid-state transformations occurring in dissolution testing
T Laaksonen, J Aaltonen - International journal of pharmaceutics, 2013 - Elsevier
Changes in the solid-state form can occur during dissolution testing of drugs. This can often
complicate interpretation of results. Additionally, there can be several mechanisms through …
complicate interpretation of results. Additionally, there can be several mechanisms through …
Solution-mediated phase transformation: significance during dissolution and implications for bioavailability
K Greco, R Bogner - Journal of pharmaceutical sciences, 2012 - Elsevier
Solubility improvement of poorly soluble drug compounds is a key approach to ensuring the
successful development of many new drugs. Methods used to improve the solubility of drug …
successful development of many new drugs. Methods used to improve the solubility of drug …
Development of Pharmaceutically Acceptable Crystalline Forms of Drug Substances via Solid-State Solvent Exchange
S Ramakrishnan, SR Yarraguntla… - … Process Research & …, 2017 - ACS Publications
In the pharmaceutical industry, solid form screening plays an important role to discover
forms that exhibit desired physicochemical properties for drug product development. This …
forms that exhibit desired physicochemical properties for drug product development. This …