Thorough understanding and control of the different crystal forms of a drug product is key for
fine chemistry and materials science; it ultimately determines the product's physicochemical …

Polymorphism is a behavior of a substance to crystallize into more than one district crystal
structures. Preferential formation of a polymorph depends strongly on the kinetics of the …

Background: In the pharmaceutical field, it is vital to ensure a consistent product containing a
single solid-state form of the active pharmaceutical ingredient (API) in the drug product …

Transformations in the solid state are of considerable interest, both for fundamental reasons
and because they underpin important technological applications. The interest spans a wide …

For the minimized phase transtorming risk, the most stable polymorph is generally
considered as the desirable solid form for pharmaceutical applications. However …

There are two major challenges in developing a solid form:(1) identifying the
thermodynamically stable form and (2) determining the method used to crystallize that form …

A major factor which determines the overall success of a pharmaceutical product is the
solidstate form in which the active pharmaceutical compound exists. It is a well-known fact …

Changes in the solid-state form can occur during dissolution testing of drugs. This can often
complicate interpretation of results. Additionally, there can be several mechanisms through …

Solubility improvement of poorly soluble drug compounds is a key approach to ensuring the
successful development of many new drugs. Methods used to improve the solubility of drug …

In the pharmaceutical industry, solid form screening plays an important role to discover
forms that exhibit desired physicochemical properties for drug product development. This …