Improved synthesis and metabolic stability analysis of the dopamine transporter ligand [18F] FECT

SK Chitneni, L Garreau, B Cleynhens, N Evens… - Nuclear medicine and …, 2008 - Elsevier
INTRODUCTION:[2′-[18F] Fluoroethyl (lR-2-exo-3-exe)-8-methyl-3-(4-chlorophenyl)-8-
azabicyclo [3.2. 1]-octane-2-carboxylate]([18F] FECT) is a positron emission tomography …

Whole-body biodistribution and dosimetry of the dopamine transporter radioligand 18F-FE-PE2I in human subjects

H Lizana, L Johansson, J Axelsson… - Journal of Nuclear …, 2018 - Soc Nuclear Med
18F-(E)-N-(3-iodoprop-2-enyl)-2β-carbofluoroethoxy-3β-(4′-methyl-phenyl) nortropane
(18F-FE-PE2I) was recently developed and has shown adequate affinity and high selectivity …

Quantification of dopamine transporter in human brain using PET with 18F-FE-PE2I

T Sasaki, H Ito, Y Kimura, R Arakawa… - Journal of Nuclear …, 2012 - Soc Nuclear Med
18F-(E)-N-(3-iodoprop-2 E-enyl)-2β-carbofluoroethoxy-3β-(4-methylphenyl) nortropane (18F-
FE-PE2I) is a new PET radioligand with a high affinity and selectivity for the dopamine …

Kinetic analysis and quantification of the dopamine transporter in the nonhuman primate brain with 11C-PE2I and 18F-FE-PE2I

A Varrone, M Tóth, C Steiger, A Takano… - Journal of Nuclear …, 2011 - Soc Nuclear Med
18F-(E)-N-(3-iodoprop-2-enyl)-2β-carbofluoroethoxy-3β-(4′-methyl-phenyl) nortropane
(18F-FE-PE2I) is a novel radioligand for dopamine transporter (DAT) PET. As compared with …

18F-labeled FECNT: a selective radioligand for PET imaging of brain dopamine transporters

MM Goodman, CD Kilts, R Keil, B Shi… - Nuclear medicine and …, 2000 - Elsevier
Fluorine-18 labeled 2β-carbomethoxy-3β-(4-chlorophenyl)-8-(2-fluoroethyl) nortropane
(FECNT) was synthesized in the development of a dopamine transporter (DAT) imaging …

PET imaging of the dopamine transporter with 18F-FECNT: a polar radiometabolite confounds brain radioligand measurements

SS Zoghbi, HU Shetty, M Ichise, M Fujita… - Journal of Nuclear …, 2006 - Soc Nuclear Med
18F-2β-Carbomethoxy-3β-(4-chlorophenyl)-8-(2-fluoroethyl) nortropane (18F-FECNT), a
PET radioligand for the dopamine transporter (DAT), generates a radiometabolite that enters …

[11C]PE2I: a highly selective radioligand for PET examination of the dopamine transporter in monkey and human brain

C Halldin, N Erixon-Lindroth, S Pauli, YH Chou… - European journal of …, 2003 - Springer
The aim of this study was to explore the potential of a new selective dopamine transporter
(DAT) compound as a radioligand for positron emission tomography (PET) examination of …

Identification and regional distribution in rat brain of radiometabolites of the dopamine transporter PET radioligand [11C]PE2I

HU Shetty, SS Zoghbi, JS Liow, M Ichise… - European journal of …, 2007 - Springer
Purpose We aimed to determine the composition of radioactivity in rat brain after intravenous
administration of the dopamine transporter radioligand,[11 C] PE2I. Methods PET time …

In vivo PET quantification of the dopamine transporter in rat brain with [18F] LBT-999

S Sérrière, C Tauber, J Vercouillie, D Guilloteau… - Nuclear Medicine and …, 2014 - Elsevier
Introduction We examined whether [18 F] LBT-999 ((E)-N-(4-fluorobut-2-enyl) 2β-
carbomethoxy-3β-(4'-tolyl) nortropane) is an efficient positron emission tomography (PET) …

Synthesis, radiolabeling and preliminary in vivo evaluation of [18F] FE-PE2I, a new probe for the dopamine transporter

M Schou, C Steiger, A Varrone, D Guilloteau… - Bioorganic & Medicinal …, 2009 - Elsevier
A new dopamine transporter (DAT) ligand,(E)-N-(3-iodoprop-2-enyl)-2β-carbofluoroethoxy-
3β-(4′-methyl-phenyl) nortropane (FE-PE2I, 6), derived from PE2I (1), was prepared and …