Testing for genetic contributions to infertility: potential clinical impact
Introduction: Male infertility affects about 7% of the general male population, and it is a
multifactorial, polygenic pathological condition. Known genetic factors, accounting for about …
multifactorial, polygenic pathological condition. Known genetic factors, accounting for about …
Genetic aspects of human male infertility: the frequency of chromosomal abnormalities and Y chromosome microdeletions in severe male factor infertility
Objective: The main purpose of this study is to detect the frequency and type of both
chromosomal abnormalities and Y chromosome microdeletions in patients with severe male …
chromosomal abnormalities and Y chromosome microdeletions in patients with severe male …
Male infertility and its causes in human
T Miyamoto, A Tsujimura, Y Miyagawa… - Advances in …, 2012 - Wiley Online Library
Infertility is one of the most serious social problems facing advanced nations. In general,
approximate half of all cases of infertility are caused by factors related to the male partner …
approximate half of all cases of infertility are caused by factors related to the male partner …
Selected genetic factors associated with male infertility
T Huynh, R Mollard, A Trounson - Human Reproduction Update, 2002 - academic.oup.com
Studies into the mechanisms underlying spermatogenesis, the process by which
spermatogonia undergo meiosis to become spermatozoa, have identified a number of …
spermatogonia undergo meiosis to become spermatozoa, have identified a number of …
Male infertility: role of genetic background
Male infertility represents one of the clearest examples of a complex disease with a
substantial genetic basis. Numerous male mouse models, mutation screening and …
substantial genetic basis. Numerous male mouse models, mutation screening and …
Genetic disorders and male infertility
S Kuroda, K Usui, H Sanjo, T Takeshima… - Reproductive …, 2020 - Wiley Online Library
Background At present, one out of six couples is infertile, and in 50% of cases, infertility is
attributed to male infertility factors. Genetic abnormalities are found in 10%‐20% of patients …
attributed to male infertility factors. Genetic abnormalities are found in 10%‐20% of patients …
Molecular genetics of infertility: loss-of-function mutations in humans and corresponding knockout/mutated mice
SY Jiao, YH Yang, SR Chen - Human reproduction update, 2021 - academic.oup.com
BACKGROUND Infertility is a major issue in human reproductive health, affecting an
estimated 15% of couples worldwide. Infertility can result from disorders of sex development …
estimated 15% of couples worldwide. Infertility can result from disorders of sex development …
[HTML][HTML] Genetic defects in human azoospermia
F Ghieh, V Mitchell, B Mandon-Pepin… - Basic and clinical …, 2019 - Springer
As with many other diseases, genetic testing in human azoospermia was initially restricted to
karyotype analyses (leading to diagnostic chromosome rearrangement tests for Klinefelter …
karyotype analyses (leading to diagnostic chromosome rearrangement tests for Klinefelter …
Chromosome studies in 952 infertile males with a sperm count below 10 million/ml
G Bourrouillou, N Dastugue, P Colomies - Human Genetics, 1985 - Springer
A major chromosomal abnormality was observed in 10.3% of subfertile men in this study.
This result is similar to a previous survey using the same criteria for selection of probands …
This result is similar to a previous survey using the same criteria for selection of probands …
Male infertility: pathogenesis and clinical diagnosis
C Krausz - Best practice & research Clinical endocrinology & …, 2011 - Elsevier
Infertility affects about 7% of all men. The etiology of impaired sperm production and function
can be related to factors acting at pre-testicular, post-testicular or directly at the testicular …
can be related to factors acting at pre-testicular, post-testicular or directly at the testicular …