The cellular level of the CDC25A phosphatase is tightly regulated during both the normal
and genotoxic-perturbed cell cycle. Here, we describe a caspase-dependent cleavage of …

Cdc25A is a dual specificity protein phosphatase that activates cyclin/cyclin-dependent
protein kinase (Cdk) complexes by removing inhibitory phosphates from conserved …

The Cdc25 dual‐specificity phosphatases control progression through the eukaryotic cell
division cycle by activating cyclin‐dependent kinases. Cdc25 A regulates entry into S‐phase …

In eukaryotic cells, control mechanisms of cell-cycle progression have evolved to accurately
monitor the integrity of genetic information to be transferred to the progeny. Cdc25A …

CDC25 dual specificity phosphatases activate the cyclin-dependent kinase complexes,
allowing timely ordered progression through out the different phases of the eukaryotic cell …

We show that Cdc6, an essential initiation factor for DNA replication, undergoes caspase-3–
mediated cleavage in the early stages of apoptosis in HeLa cells and SK-HEP-1 cells …

The CDC25 dual specificity phosphatase is a universal cell cycle regulator. The evolutionary
conservation of this enzyme from yeast to man bears witness to its major role in the control of …

The dual specificity phosphatase Cdc25B is capable of inhibiting cellular proliferation, and
this occurs in a manner dependent upon its catalytic activity. Here it is shown that this is …

The human Cdc25A phosphatase plays a pivotal role at the G 1/S transition by activating
cyclin E and A/Cdk2 complexes through dephosphorylation. In response to ionizing …

CDC25 phosphatases control cell-cycle progression by dephosphorylating and activating
cyclin-dependent kinases. CDC25B, one of the three members of this family in human cells …