Glycerophospholipids, the structural components of cell membranes, have not been
considered to be spatial cues for intercellular signaling because of their ubiquitous …

Despite the crucial role that prostaglandins (PGs) have in the sensitization of the central
nervous system to pain, their cellular and molecular targets leading to increased pain …

Lysophosphatidic acid (LPA) is a bioactive lipid with activity in the nervous system mediated
by G-protein-coupled receptors. Here, we examined the role of LPA signaling in the …

Axon guidance requires signal transduction of extracellular cues through the plasma
membrane for directional motility. Here we present evidence that cholesterol-and …

Prostaglandin E2 (PGE2) is a crucial mediator of inflammatory pain sensitization. Here, we
demonstrate that inhibition of a specific glycine receptor subtype (GlyR α3) by PGE2 …

Schwann cell (SC) migration is an important step preceding myelination and remyelination
in the peripheral nervous system, and can be promoted by peptide factors like neuregulins …

The six-transmembrane protein glycerophosphodiester phosphodiesterase 2 (GDE2)
induces spinal motor neuron differentiation by inhibiting Notch signaling in adjacent motor …

INTRODUCTION Axons grow collateral branches to project to distinct target areas in the
central nervous system (CNS) and to form synapses with various postsynaptic partner cells …

The myelin sheath allows axons to conduct action potentials rapidly in the vertebrate
nervous system. Axonal signals activate expression of specific transcription factors …

Mutations in GPR56, a member of the adhesion G protein-coupled receptor family, cause a
human brain malformation called bilateral frontoparietal polymicrogyria (BFPP). Magnetic …