Blood production is ensured by rare, self-renewing haematopoietic stem cells (HSCs). How
HSCs accommodate the diverse cellular stresses associated with their life-long activity …

With age, haematopoietic stem cells lose their ability to regenerate the blood system, and
promote disease development. Autophagy is associated with health and longevity, and is …

The activation of mostly quiescent haematopoietic stem cells (HSCs) is a prerequisite for life-
long production of blood cells. This process requires major molecular adaptations to allow …

Hematopoietic stem cells (HSC) are primarily dormant but have the potential to become
highly active on demand to reconstitute blood. This requires a swift metabolic switch from …

Haematopoietic stem cells (HSCs) differ from their committed progeny by relying primarily on
anaerobic glycolysis rather than mitochondrial oxidative phosphorylation for energy …

Haematopoietic stem and progenitor cells are maintained by special microenvironments
known as niches in bone marrow,,,,,. Many studies have identified diverse candidate cells …

The mouse hematopoietic stem cell (HSC) is probably the best-understood somatic stem cell
in higher organisms. Recent studies have shown that the highest self-renewal potential is …

A single hematopoietic stem cell (HSC) is capable of reconstituting hematopoiesis and
maintaining homeostasis by balancing self-renewal and cell differentiation. The …

Ageing in multicellular organisms typically involves a progressive decline in cell
replacement and repair processes, resulting in several physiological deficiencies, including …

Chimeric antigen receptor (CAR) T cell therapy has transformed the treatment of
haematological malignancies such as acute lymphoblastic leukaemia, B cell lymphoma and …