Distinct Nrf2 signaling mechanisms of fumaric acid esters and their role in neuroprotection against 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced …
M Ahuja, NA Kaidery, L Yang… - Journal of …, 2016 - Soc Neuroscience
A promising approach to neurotherapeutics involves activating the nuclear-factor-E2-related
factor 2 (Nrf2)/antioxidant response element signaling, which regulates expression of …
factor 2 (Nrf2)/antioxidant response element signaling, which regulates expression of …
The neuroprotective effect of dimethyl fumarate in an MPTP-mouse model of Parkinson's disease: involvement of reactive oxygen species/nuclear factor-κB/nuclear …
M Campolo, G Casili, F Biundo, R Crupi… - Antioxidants & redox …, 2017 - liebertpub.com
Aim: Oxidative stress plays a key role in Parkinson disease (PD), and nuclear transcription
factor related to NF-E2 (Nrf-2) is involved in neuroprotection against PD. The aim of the …
factor related to NF-E2 (Nrf-2) is involved in neuroprotection against PD. The aim of the …
Dimethyl fumarate attenuates 6-OHDA-induced neurotoxicity in SH-SY5Y cells and in animal model of Parkinson's disease by enhancing Nrf2 activity
X Jing, H Shi, C Zhang, M Ren, M Han, X Wei, X Zhang… - Neuroscience, 2015 - Elsevier
Oxidative stress is central to the pathology of several neurodegenerative diseases, including
Parkinson's disease (PD), and therapeutics designed to enhance antioxidant potential could …
Parkinson's disease (PD), and therapeutics designed to enhance antioxidant potential could …
Ferulic Acid Ameliorates MPP+/MPTP-Induced Oxidative Stress via ERK1/2-Dependent Nrf2 Activation: Translational Implications for Parkinson Disease Treatment
X Li, J Zhang, H Rong, X Zhang, M Dong - Molecular neurobiology, 2020 - Springer
Parkinson's disease (PD) is a neurodegenerative disorder closely associated with oxidative
stress. The biochemical and cellular alterations that occur after cell and mouse treatment …
stress. The biochemical and cellular alterations that occur after cell and mouse treatment …
Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway
RA Linker, DH Lee, S Ryan, AM van Dam, R Conrad… - Brain, 2011 - academic.oup.com
Inflammation and oxidative stress are thought to promote tissue damage in multiple
sclerosis. Thus, novel therapeutics enhancing cellular resistance to free radicals could prove …
sclerosis. Thus, novel therapeutics enhancing cellular resistance to free radicals could prove …
Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP mouse model of Parkinson's …
NA Kaidery, R Banerjee, L Yang… - Antioxidants & redox …, 2013 - liebertpub.com
Although the etiology of Parkinson's disease (PD) remains unclear, ample empirical
evidence suggests that oxidative stress is a major player in the development of PD and in 1 …
evidence suggests that oxidative stress is a major player in the development of PD and in 1 …
Antioxidant and anti-inflammatory effect of Nrf2 inducer dimethyl fumarate in neurodegenerative diseases
SA Scuderi, A Ardizzone, I Paterniti, E Esposito… - Antioxidants, 2020 - mdpi.com
Neurodegenerative diseases (NDs) represents debilitating conditions characterized by
degeneration of neuronal cells in specific brain areas, causing disability and death in …
degeneration of neuronal cells in specific brain areas, causing disability and death in …
Pharmacological targeting of the transcription factor Nrf2 at the basal ganglia provides disease modifying therapy for experimental parkinsonism
A Jazwa, AI Rojo, NG Innamorato, M Hesse… - Antioxidants & redox …, 2011 - liebertpub.com
Current therapies for motor symptoms of Parkinson's disease (PD) are based on dopamine
replacement. However, the disease progression remains unaffected, because of continuous …
replacement. However, the disease progression remains unaffected, because of continuous …
In vivo modulation of the Parkinsonian phenotype by Nrf2
NC Burton, TW Kensler, TR Guilarte - Neurotoxicology, 2006 - Elsevier
Oxidative stress has been implicated in the etiology of Parkinson's disease (PD) and in the 1-
methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) animal model of PD. In this report we …
methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) animal model of PD. In this report we …
Identification of Novel Protein Targets of Dimethyl Fumarate Modification in Neurons and Astrocytes Reveals Actions Independent of Nrf2 Stabilization*[S]
GG Piroli, AM Manuel, T Patel, MD Walla, L Shi… - Molecular & Cellular …, 2019 - ASBMB
The fumarate ester dimethyl fumarate (DMF) has been introduced recently as a treatment for
relapsing remitting multiple sclerosis (RRMS), a chronic inflammatory condition that results …
relapsing remitting multiple sclerosis (RRMS), a chronic inflammatory condition that results …