Synthesis and evaluation of the activity of new 4-methyl-1, 2, 3, 4, 10, 10a-
hexahydropyrazino [1, 2-a] indoles as 5-HT2C receptor agonists are described …

The preparation of a series of conformationally restricted analogues of indolylurea 1, namely
tetrahydropyrroloindoles and tetrahydropyrroloquinolines, is described. The binding …

The syntheses, structure-activity relationships (SARs), and biological activities of
tetrahydroquinoline-based tricyclic amines as 5-HT 2C receptor agonists are reported. An …

Structural modification of the 2-methoxy group and at the 4-position of the piperidine ring of
the 5-HT 4 partial agonist 1 led to analogues with increased affinity for the 5-HT 4 receptor …

1-Aminoethyl-3-arylsulfonyl-1H-indoles 1 are 5-HT6 receptor ligands with modest activity in
a 5-HT6 cyclase assay. Introduction of an additional nitrogen in the indole ring provides 1 …

A series of substituted 4-arylpiperidines and a smaller family of 4-aryl-1, 2, 3, 6-
tetrahydropyridines were synthesized and their biological activity at the 5-HT2C receptor …

A series of 4-hydroxy-3-quinolinecarboxylic acid derivatives (6) and 4-hydroxy-2-oxo-1, 2-
dihydro-3-quinolinecarboxylic acid derivatives (7) were designed and synthesized as 5-HT3 …

In continuation of our previous work on piperazinopyrrolothienopyrazine derivatives, three
series of piperazinopyridopyrrolopyrazines, piperazinopyrroloquinoxalines, and …

The 5-HT2C receptor is one of three closely related receptor subtypes in the 5-HT2 receptor
family. 5-HT2A and 5-HT2B selective antagonists have been described. However, no 5 …

Synthesis and pharmacological evaluation of a series of condensed quinoline and pyridine
derivatives bearing a N-methylpiperazine moiety attached to the 2-position of the quinoline …