Background Increased apposition of the frontal and parietal bones of the skull during
embryogenesis may be a risk factor for the subsequent development of premature skull …

Abstract Background The highly conserved Grainyhead‐like (Grhl) family of transcription
factors play critical roles in the development of the neural tube and craniofacial skeleton. In …

The genetic basis of human neural tube defects (NTDs), such as anencephaly and spina
bifida (SB), is complex and heterogeneous. Grainyhead-like genes represent candidates for …

The highly-conserved Grainyhead-like (Grhl) transcription factors are critical regulators of
embryogenesis that regulate cellular survival, proliferation, migration and epithelial integrity …

Craniofacial development in vertebrates involves the coordinated growth, migration, and
fusion of several facial prominences during embryogenesis, processes governed by strict …

Grainyhead‐like genes are part of a highly conserved gene family that play a number of
roles in ectoderm development and maintenance in mammals. Here we identify a novel …

The highly conserved Grainyhead‐like (Grhl) family of transcription factors, comprising three
members in vertebrates (Grhl1‐3), play critical regulatory roles during embryonic …

Coordinated growth of the skull and brain are vital to normal human development.
Craniosynostosis, the premature fusion of the calvarial bones of the skull, is a relatively …

The development of the mammalian skull is a complex process that requires multiple tissue
interactions and a balance of growth and differentiation. Disrupting this balance can lead to …

The Drosophila grainyhead (grh) and vertebrate Grainyhead-like (Grhl) transcription factors
are among the most critical genes for epithelial development, maintenance and …