Gene therapy has the potential to improve the clinical outcome of many cancers by
transferring therapeutic genes into tumor cells or normal host tissue. Gene transfer into …

In order to realise the full potential of gene therapy as a rational approach to the treatment of
cancer, it will be necessary to achieve delivery of the therapeutic gene selectively to target …

Gene therapy has the potential to provide highly selective, curative cancer treatments
without inducing systemic toxicity. Adenoviral vectors have been extensively used for cancer …

For long it has been recognized that tumor necrosis factor alpha (TNFa) has anticancer
characteristics, and its use as a cancer therapeutic was proposed already in the 1980s …

The human parvovirus adeno-associated virus type 2 (AAV-2) possesses many features that
make it an attractive vector for gene delivery in vivo. However, its broad host range may limit …

Purpose: The aim of this study is to explore a novel strategy through which the differential
production of pro-angiogenic cytokines within the tumor microenvironment can be exploited …

A major impediment to the successful application of gene therapy for the treatment of a
range of diseases is not a paucity of therapeutic genes, but the lack of an efficient non‐toxic …

Background The aim of the present study was to develop and characterize a novel in vivo
cancer gene therapy model in which intra-arterial adenoviral gene delivery can be …

Clinical gene therapy for cardiovascular disease remains achievable. To date, however,
preclinical studies and clinical trials have highlighted shortfalls in viral gene delivery to …

Chondrosarcoma is a cartilage‐forming bone tumor, well known for intrinsic resistance to
chemotherapy and radiotherapy. We have designed a targeted chondrosarcoma gene …