Over the past 20 years there has been a great deal of research into those considered to be
at risk for developing psychosis. Much has been learned and studies have been …

One of the major advances over the past 20 years in psychiatry is the capacity not only to
identify people at incipient risk for psychosis and other disabling mental disorders, but also …

Prediction and prevention of negative clinical and functional outcomes represent the two
primary objectives of research conducted within the clinical high-risk for psychosis (CHR-P) …

Context During the past 2 decades, a major transition in the clinical characterization of
psychotic disorders has occurred. The construct of a clinical high-risk (HR) state for …

Background: The first rate-limiting step for improving outcomes of psychosis through
preventive interventions in people at clinical high risk for psychosis (CHR-P) is the ability to …

Two decades of research in the context of clinical high risk (CHR) for psychosis has
addressed a time-honored value in medicine 1: early detection and intervention to reduce …

Twenty percent of individuals at clinical high risk for psychosis (CHR-P) develop the disorder
within 2 years. Extensive research has explored the factors that differentiate those who …

Background Malhi et al. in this issue critique the clinical high risk (CHR) syndrome for
psychosis. Method Response to points of critique. Results We agree that inconsistency in …

Background: The Clinical High Risk state for Psychosis (CHR-P) has become the
cornerstone of modern preventive psychiatry. The next stage of clinical advancements rests …

Abstract The Clinical High-Risk state for psychosis (CHR-P) paradigm was introduced about
2 decades ago. Over this period of time accumulating knowledge has been gained …