[HTML][HTML] Analysis of genetics and DNA methylation in osteoarthritis: what have we learnt about the disease?
LN Reynard - Seminars in Cell & Developmental Biology, 2017 - Elsevier
Osteoarthritis (OA) is a chronic musculoskeletal disease characterised by the destruction of
articular cartilage, synovial inflammation and bone remodelling. Disease aetiology is …
articular cartilage, synovial inflammation and bone remodelling. Disease aetiology is …
[HTML][HTML] DNA methylation in osteoarthritis: current status and therapeutic implications
A Miranda-Duarte - The open rheumatology journal, 2018 - ncbi.nlm.nih.gov
Background: Primary Osteoarthritis (OA) is a multifactorial disease in which genetic factors
are strongly associated with its development; however, recently it has been observed that …
are strongly associated with its development; however, recently it has been observed that …
[HTML][HTML] DNA methylation in osteoarthritic chondrocytes: a new molecular target
HI Roach, T Aigner - Osteoarthritis and cartilage, 2007 - Elsevier
OBJECTIVE: To review the current knowledge of the mechanism of DNA methylation, its
association with transcriptional silencing, possible mechanisms of hyper-and …
association with transcriptional silencing, possible mechanisms of hyper-and …
DNA methylation in osteoarthritis
W den Hollander, I Meulenbelt - Current Genomics, 2015 - ingentaconnect.com
Osteoarthritis (OA) is a prevalent disease of articular joints and primarily characterized by
degradation and calcification of articular cartilage. Presently, no effective treatment other …
degradation and calcification of articular cartilage. Presently, no effective treatment other …
The epigenomic landscape in osteoarthritis
TC Simon, MA Jeffries - Current rheumatology reports, 2017 - Springer
Abstract Purpose of Review Epigenomics has emerged as a key player in our rapidly
evolving understanding of osteoarthritis. Historical studies implicated epigenetic alterations …
evolving understanding of osteoarthritis. Historical studies implicated epigenetic alterations …
Methylation quantitative trait locus analysis of osteoarthritis links epigenetics with genetic risk
MD Rushton, LN Reynard, DA Young… - Human molecular …, 2015 - academic.oup.com
Osteoarthritis (OA) is a common, painful and debilitating disease of articulating joints
resulting from the age-associated loss of cartilage. Well-powered genetic studies have …
resulting from the age-associated loss of cartilage. Well-powered genetic studies have …
Epigenetics of osteoarticular diseases: recent developments
SB Roberts, E Wootton, L De Ferrari… - Rheumatology …, 2015 - Springer
A variety of osteoarticular conditions possess an underlying genetic aetiology. Large-scale
genome-wide association studies have identified several genetic loci associated with …
genome-wide association studies have identified several genetic loci associated with …
Genome‐wide DNA methylation study identifies significant epigenomic changes in osteoarthritic cartilage
MA Jeffries, M Donica, LW Baker… - Arthritis & …, 2014 - Wiley Online Library
Objective To perform a genome‐wide DNA methylation study to identify DNA methylation
changes in osteoarthritic (OA) cartilage tissue. Methods The contribution of differentially …
changes in osteoarthritic (OA) cartilage tissue. Methods The contribution of differentially …
Epigenetic regulation in knee osteoarthritis
Z Cai, T Long, Y Zhao, R Lin, Y Wang - Frontiers in Genetics, 2022 - frontiersin.org
Osteoarthritis (OA) is a complicated disease with both hereditary and environmental causes.
Despite an increase in reports of possible OA risk loci, it has become clear that genetics is …
Despite an increase in reports of possible OA risk loci, it has become clear that genetics is …
Transcriptional associations of osteoarthritis‐mediated loss of epigenetic control in articular cartilage
Objective To identify osteoarthritis (OA) progression–modulating pathways in articular
cartilage and their respective regulatory epigenetic and genetic determinants in end‐stage …
cartilage and their respective regulatory epigenetic and genetic determinants in end‐stage …