Obstructive sleep apnea (OSA) is a major source of cardiovascular morbidity and mortality,
and represents an increasing burden on health care resources. Understanding underlying …

Considerable progress has been made over the last several decades in our understanding
of the pathophysiology of both central and obstructive sleep apnea. Central sleep apnea, in …

Obstructive sleep apnea (OSA) is a common disorder characterized by repetitive narrowing
or collapse of the pharyngeal airway during sleep. The disorder is associated with major …

Obstructive sleep apnea (OSA) is characterized by intermittent inspiratory closure of the
pharyngeal airway during sleep resulting in episodic hypoxemia and sleep disruption …

Obstructive sleep apnea (OSA) is a common disorder characterized by repetitive collapse of
the pharyngeal airway during sleep. Control of pharyngeal patency is a complex process …

Obstructive sleep apnea (OSA) is characterised by recurring episodes of upper airway
obstruction during sleep and the fundamental abnormality reflects the inability of the upper …

Ongoing studies are attempting to classify patients on the basis of the underlying
pathophysiology. This work suggests that obstructive sleep apnea is a heterogeneous …

This paper focuses on the underlying mechanisms contributing to sleep-disordered
breathing. Obstructive sleep apnea (OSA) is the most common sleep-related breathing …

We review evidence in support of significant contributions to the pathogenesis of obstructive
sleep apnea (OSA) from pathophysiological factors beyond the well-accepted importance of …

We determined whether upper airway obstruction in normal individuals with intact reflexes
could produce the syndrome of obstructive sleep apnea. Upper airway obstruction was …