Osteosarcoma Classic high-grade osteosarcoma is a highly malignant spindle-cell sarcoma
of bone in which the malignant cells produce osteoid1. It is the most common primary …

Werner's syndrome, a relatively rare and autosomal recessive disorder, is well known to be
characterized by a high frequency of malignant neoplasm. The occurrence of familial …

Maffucci's syndrome is characterized by multiple enchondromas and subcutaneous
hemangiomas. These tumors typically present in early childhood and may lead to significant …

Three of nine children of possibly consanguineous American Indian parents developed
typical osteosarcoma in a 2‐year period. Etiologic investigations detected limb anomalies …

Inherited skeletal disorders have a fascination for many medical and surgical disciplines. For
the geneticist there is interest in the study of families and their inheritance of lesions. The …

Cartilaginous bone tumors have long been recognized as a distinct entity. For example, in
1899 Ollier recognized a sporadic dyschondroplasia that resulted from a developmental …

Discussion It is well known that in certain pre-existing benign conditions, particularly Paget
disease” and bone infarct9, osteogenic sarcoma is prone to occur. Solitary cases of …

Werner syndrome is an autosomal-recessive disease characterized by premature aging,
shortness of stature, scleroderma-like skin changes, endocrine abnormalities, and cataracts …

Gardner syndrome, a variant of familial adenomatous polyposis, is an autosomal dominant
disease characterized by gastrointestinal polyps that develop in the colon as well as in the …

In 1951, Gardner1reported the association between surface tumors and colonic polyps that
are prone to malignant degeneration. In 1952, Gardner and Plenk2 described the dominant …